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Literature summary for 3.1.1.4 extracted from
- Identification of a novel and potent inhibitor of phospholipase A 2 in a medicinal plant: Crystal structure at 1.93 A and Surface Plasmon Resonance analysis of phospholipase A2 complexed with berberine (2011), Biochim. Biophys. Acta, 1814, 657-663.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| phospholipase A2 complexed with berberine, hanging drop vapor diffusion method, using 5 mM CaCl2 in 25 mM sodium acetate buffer of pH 6.2 with 15% (w/v) polyethylene glycol 8000 and 0.2 M ammonium sulfate | Daboia russelii russelii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ajmaline | - |
Daboia russelii russelii |  |
| Anisic acid | - |
Daboia russelii russelii | |
| aristolochic acid | - |
Daboia russelii russelii | |
| Berberine | competitive inhibitor of phospholipase A2 | Daboia russelii russelii | |
| diclofenac | - |
Daboia russelii russelii | |
| oxyphenbutazone | - |
Daboia russelii russelii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
soya lecithin | at pH 8.9, temperature not specified in the publication | Daboia russelii russelii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| soya lecithin + H2O | Daboia russelii russelii | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Daboia russelii russelii | P59071 | Indian Russell's viper, chain viper | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Daboia russelii russelii | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| soya lecithin + H2O | - |
Daboia russelii russelii | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLA2 | - |
Daboia russelii russelii |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
Berberine | at pH 8.9, temperature not specified in the publication | Daboia russelii russelii | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.087 | - |
at pH 8.9, temperature not specified in the publication | Daboia russelii russelii | Berberine | |
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Release 2023.1 (January 2023)
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