Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[2-aminoethyl]benzensulfonyl fluoride | pefabloc, inhibition of activity at 1 mM | Mus musculus | |
additional information | during low density lipoprotein oxidation with 0.005 mM CuSO4, the remaining Lp-PLA2 activity after 6h is approximately 40-50% while after 24h only 10-15% of the initial activity is preserved | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
Western blot analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female BALB/c mice | - |
Purification (Comment) | Organism |
---|---|
partially purified by gel filtration and on anion exchange column | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
peritoneal macrophage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-arachidonoyl-phosphatidylcholine + H2O | - |
Mus musculus | ? | - |
? | |
l-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Mus musculus | ? | - |
? | |
oxidized phosphatidylcholine + H2O | great amount of oxidized phosphatidylcholine of oxidized LDL is hydrolyzed at the sn-2 position | Mus musculus | lysophosphatidylcholine + fatty acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipoprotein associated phospholipase A2 | - |
Mus musculus |
Lp-PLA2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | progressive inactivation of Lp-PLA2 during low density lipoprotein oxidation leads to an increased uptake of oxidized low density lipoprotein by macrophages, which can be primarily attributed to the increased uptake of the oxidized phospholipids enriched lipid moiety of oxidized low density lipoprotein. Inhibition of Lp-PLA2 activity has no effect on the uptake of ApoB-liposomes conjugates with ApoB isolated from moderately oxidized low density lipoprotein, moderately oxidized low density lipoprotein with inhibited LpPLA2 activity, heavily oxidized low density lipoprotein and heavily oxidized low density lipoprotein with inhibited LpPLA2 activity | Mus musculus |
physiological function | Lp-PLA2 activity reduces the uptake of oxidized low density lipoprotein by peritoneal macrophages. Lp-PLA2 does not affect the uptake of oxidized low density lipoprotein via the ApoB moiety. Lp-PLA2 reduces the uptake of oxidized low density lipoprotein via the lipid moiety | Mus musculus |