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Literature summary for 3.1.1.4 extracted from

  • Bhattacharya, A.; Muller, F.L.; Liu, Y.; Sabia, M.; Liang, H.; Song, W.; Jang, Y.C.; Ran, Q.; Van Remmen, H.
    Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria (2009), J. Biol. Chem., 284, 46-55.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
arachidonyl trifluoromethyl ketone AACOCF3, highly selective cPLA2 inhibitor, inhibits the Amplex Red signal in mitochondria from denervated muscle and from Sod1-/- mice Mus musculus
bromoenol lactone iPLA2 inhibitor, does not inhibit the Amplex Red signal Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hindlimb
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cPLA2 may release fatty acid hydroperoxides from membranes following denervation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
calcium-independent phospholipase A2
-
 Mus musculus
cPLA2
-
 Mus musculus
cytosolic phospholipase A2
-
 Mus musculus
iPLA2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus cPLA2 protein levels are increased ca. 2fold in muscle homogenates 7 days post-denervation. The cPLA2 protein levels are also elevated in Sod1-/- and G93A mice up

General Information

General Information Comment Organism
physiological function cPLA2 may be a potential source of fatty acid hydroperoxides. cPLA2 is a key mediator of the high state 1 Amplex Red signal (thought to be highly specific for hydrogen peroxide) that occurs in response to denervation, most likely by preventing the release of fatty acid hydroperoxides from lipid hydroperoxides in the bilayer. Elevation of cPLA2 is potentially a common phenomenon in mice that exhibit muscle atrophy associated with a loss of innervation Mus musculus