Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
limb | mesenchymal cell | Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-linoleoyl-sn-glycerophosphorylethanolamine + H2O | - |
Gallus gallus | 1-palmitoyl-glycerophosphorylethanolamine + linoleic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
secretory phospholipase A2 | - |
Gallus gallus |
sPLA2 | - |
Gallus gallus |
Organism | Comment | Expression |
---|---|---|
Gallus gallus | secretion of sPLA2 during limb development | up |
General Information | Comment | Organism |
---|---|---|
physiological function | sPLA2 influences the proliferation and/or survival of limb mesenchymal cells. Treatment of wing bud mesenchymal cells with exogenous sPLA2 promotes cell death by activating MMP-9 (matrix metalloproteinase-9) through receptor-mediated signalling and increasing type I collagen degradation. Chondro-inhibitory actions by sPLA2 are prevented by functional blocking of FcRY (chicken yolk sac IgY receptor) and by inhibition of ERK (extracellular-signal-regulated kinase) activity | Gallus gallus |