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Literature summary for 3.1.1.4 extracted from

  • Oslund, R.C.; Cermak, N.; Gelb, M.H.
    Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2 (2008), J. Med. Chem., 51, 4708-4714.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
([1-[amino(oxo)acetyl]-3-(biphenyl-2-ylmethyl)-2-(2-methylpropyl)indolizin-8-yl]oxy)acetic acid
-
 Homo sapiens
([1-[amino(oxo)acetyl]-3-(biphenyl-2-ylmethyl)-2-(2-methylpropyl)indolizin-8-yl]oxy)acetic acid
-
 Mus musculus
([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)acetic acid
-
 Homo sapiens
([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)acetic acid
-
 Mus musculus
2-(1-benzyl-2-ethyl-4-methoxy-1H-benzo[g]indol-3-yl)-2-oxoacetamide
-
 Homo sapiens
2-(1-benzyl-2-ethyl-4-methoxy-1H-benzo[g]indol-3-yl)-2-oxoacetamide
-
 Mus musculus
2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-6,7-benzoindol-4-yloxy)acetic acid
-
 Homo sapiens
2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-6,7-benzoindol-4-yloxy)acetic acid
-
 Mus musculus
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Mus musculus
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(methylsulfonyl)propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Mus musculus
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(2-chlorophenyl)sulfonyl]propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(2-methylphenyl)sulfonyl]propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(3-chlorophenyl)sulfonyl]propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(4-chlorophenyl)sulfonyl]propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(4-methylphenyl)sulfonyl]propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(trifluoromethyl)sulfonyl]propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[[2-(trifluoromethyl)phenyl]sulfonyl]propanamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Mus musculus
2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Homo sapiens
2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
 Mus musculus
2-[1-benzyl-2-(2-methylpropyl)-4-(2-oxopropoxy)-1H-indol-3-yl]-2-oxoacetamide
-
 Homo sapiens
2-[1-benzyl-2-(2-methylpropyl)-4-(2-oxopropoxy)-1H-indol-3-yl]-2-oxoacetamide
-
 Mus musculus
2-[1-benzyl-4-(2-oxopropoxy)-2-propyl-1H-indol-3-yl]-2-oxoacetamide
-
 Homo sapiens
2-[1-benzyl-4-(2-oxopropoxy)-2-propyl-1H-indol-3-yl]-2-oxoacetamide
-
 Mus musculus
2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-(2-oxopropoxy)indolizin-1-yl]-2-oxoacetamide
-
 Homo sapiens
2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-(2-oxopropoxy)indolizin-1-yl]-2-oxoacetamide
-
 Mus musculus
2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-methoxyindolizin-1-yl]-2-oxoacetamide
-
 Homo sapiens
2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-methoxyindolizin-1-yl]-2-oxoacetamide
-
 Mus musculus
indoxam
-
 Homo sapiens
indoxam
-
 Mus musculus
LY315920
-
 Homo sapiens
LY315920 i.e. [[3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetate Mus musculus
additional information substituted indole and 6,7-benzoindole inhibitor binding, molecular modeling, overview Homo sapiens
additional information substituted indole and 6,7-benzoindole inhibitor binding, molecular modeling, overview Mus musculus
tert-butyl ([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)acetate
-
 Homo sapiens
tert-butyl ([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)acetate
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
More secreted phospholipase A2 isozymes from groups A, B, D, E, F, V, and X Mus musculus
More secreted phospholipase A2 isozymes from groups A, B, D, E, F, V, and X Homo sapiens
secreted phospholipases A2
-
 Mus musculus
secreted phospholipases A2
-
 Homo sapiens
sPLA2
-
 Mus musculus
sPLA2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 values of diverse isozymes, overview Mus musculus additional information
additional information
-
 IC50 values of diverse isozymes, overview Homo sapiens additional information
0.000006
-
 isozyme sPLA2 group IIX Mus musculus 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-6,7-benzoindol-4-yloxy)acetic acid
0.000007
-
 isozyme sPLA2 group IIE Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.000007
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(methylsulfonyl)propanamide
0.000007
-
 isozymes sPLA2 group IIE and IID Homo sapiens 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-6,7-benzoindol-4-yloxy)acetic acid
0.000009
-
 isozyme sPLA2 group IIE Homo sapiens 2-[1-benzyl-4-(2-oxopropoxy)-2-propyl-1H-indol-3-yl]-2-oxoacetamide
0.00001
-
 isozyme sPLA2 group IIE Homo sapiens indoxam
0.00001
-
 isozyme sPLA2 group IIX Homo sapiens ([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)acetic acid
0.000011
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(2-methylphenyl)sulfonyl]propanamide
0.000012
-
 isozyme sPLA2 group IIE Mus musculus 2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.000014
-
 isozyme sPLA2 group IIA Homo sapiens 2-(1-benzyl-2-ethyl-4-methoxy-1H-benzo[g]indol-3-yl)-2-oxoacetamide
0.000014
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(2-chlorophenyl)sulfonyl]propanamide
0.000016
-
 isozyme sPLA2 group IIE Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.00002
-
 isozyme sPLA2 group IIX Mus musculus 2-[1-benzyl-4-(2-oxopropoxy)-2-propyl-1H-indol-3-yl]-2-oxoacetamide
0.000021
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.00003
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.00003
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(trifluoromethyl)sulfonyl]propanamide
0.000034
-
 isozyme sPLA2 group IIA Mus musculus 2-(1-benzyl-2-ethyl-4-methoxy-1H-benzo[g]indol-3-yl)-2-oxoacetamide
0.000035
-
 isozyme sPLA2 group IIA Homo sapiens 2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-methoxyindolizin-1-yl]-2-oxoacetamide
0.000035
-
 isozyme sPLA2 group IIE Mus musculus indoxam
0.000035
-
 isozyme sPLA2 group IIX Mus musculus 2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.00005
-
 isozyme sPLA2 group IIE Homo sapiens LY315920
0.00005
-
 isozyme sPLA2 group IIX Homo sapiens 2-[1-benzyl-2-(2-methylpropyl)-4-(2-oxopropoxy)-1H-indol-3-yl]-2-oxoacetamide
0.00007
-
 isozyme sPLA2 group IIA Mus musculus LY315920
0.00007
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[[2-(trifluoromethyl)phenyl]sulfonyl]propanamide
0.00008
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)propanamide
0.00013
-
 isozyme sPLA2 group IIF Mus musculus ([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)acetic acid
0.00014
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(3-chlorophenyl)sulfonyl]propanamide
0.00023
-
 isozyme sPLA2 group IIE Mus musculus 2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-methoxyindolizin-1-yl]-2-oxoacetamide
0.00032
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(4-methylphenyl)sulfonyl]propanamide
0.00041
-
 isozyme sPLA2 group IIE Mus musculus 2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-(2-oxopropoxy)indolizin-1-yl]-2-oxoacetamide
0.00045
-
 isozyme sPLA2 group IIF Mus musculus 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.00054
-
 isozyme sPLA2 group IIX Homo sapiens 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(4-chlorophenyl)sulfonyl]propanamide
0.00058
-
 isozyme sPLA2 group IIB Mus musculus 2-[1-benzyl-2-(2-methylpropyl)-4-(2-oxopropoxy)-1H-indol-3-yl]-2-oxoacetamide
0.00097
-
 isozyme sPLA2 group IIF Homo sapiens ([1-[amino(oxo)acetyl]-3-(biphenyl-2-ylmethyl)-2-(2-methylpropyl)indolizin-8-yl]oxy)acetic acid
0.0011
-
 isozyme sPLA2 group IIF Mus musculus ([1-[amino(oxo)acetyl]-3-(biphenyl-2-ylmethyl)-2-(2-methylpropyl)indolizin-8-yl]oxy)acetic acid
0.0016
-
 above, isozyme sPLA2 group IIA-IIX Mus musculus 2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
0.009
-
 isozyme sPLA2 group IIE Homo sapiens 2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-(2-oxopropoxy)indolizin-1-yl]-2-oxoacetamide