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Literature summary for 3.1.1.4 extracted from
- Purification, characterization and bactericidal activities of basic phospholipase A2 from the venom of Agkistrodon halys (Chinese pallas) (2008), Biochimie, 90, 1372-1388.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Gloydius halys | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Gloydius halys | AgkTx-II exerts a potent antibacterial activity against Staphylococcus aureus, Proteus vulgaris, Proteus mirabilis, and Burkholderia pseudomallei. The MIC values of AgkTx-II range between 0.085 and 0.00276 mM. AgkTx-II exhibits no hemolytic action even at high doses in human erythrocytes. AgkTx-II treated mice show severe neurotoxicity, whereas in the skin, no alterations of skin myotoxicity are observed, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gloydius halys | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from venom by gel filtration and C8 reverse phase HPLC | Gloydius halys |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Gloydius halys | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | AgkTx-II exerts a potent antibacterial activity against Staphylococcus aureus, Proteus vulgaris, Proteus mirabilis, and Burkholderia pseudomallei. The MIC values of AgkTx-II range between 0.085 and 0.00276 mM. AgkTx-II exhibits no hemolytic action even at high doses in human erythrocytes. AgkTx-II treated mice show severe neurotoxicity, whereas in the skin, no alterations of skin myotoxicity are observed, overview | Gloydius halys | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AgkTx-II | - |
Gloydius halys |
| Asp49 basic myotoxic PLA2 | - |
Gloydius halys |
| basic Asp49 PLA2 | - |
Gloydius halys |
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