Application | Comment | Organism |
---|---|---|
drug development | development of Lp-PLA2 inhibitors as therapy for atherosclerosis | Homo sapiens |
pharmacology | development of Lp-PLA2 inhibitors as therapy for atherosclerosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SB222657 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Homo sapiens | the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview | 1-acylglycerophosphocholine + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions of blood vessels, it predominantly circulates as a constituent of LDL particles | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | long chain oxidized phosphatidylcholines represent quantitatively the most abundant phosphatidylcholine products of LDL oxidation, although they are less efficient as substrates for Lp-PLA2 than are the short chain oxidized phosphoatidylcholines | Homo sapiens | ? | - |
? | |
phosphatidylcholine + H2O | the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview | Homo sapiens | 1-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | substrate is derived from human carotid artery plaques | Homo sapiens | 1-acylglycerophosphocholine + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipoprotein-associated phospholipase A2 | - |
Homo sapiens |
Lp-PLA2 | - |
Homo sapiens |
More | cf. EC 3.1.1.34 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |