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Literature summary for 3.1.1.4 extracted from
- Purification, sequencing and structural analysis of two acidic phospholipases A2 from the venom of Bothrops insularis (jararaca ilhoa) (2006), Biochimie, 88, 1947-1959.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozymes BinTx-I and BinTx-II, DNA and amino acid sequence determination and analysis, phylogenetic analysis, sequence comparisons, overview | Bothrops insularis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | isozymes BinTx-I and BinTx-II | Bothrops insularis | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 13788 | - |
x * 13975, isozyme BinTx-I, sequence calculation, x * 13788, isozyme BinTx-II, sequence calculation | Bothrops insularis |
| 13975 | - |
x * 13975, isozyme BinTx-I, sequence calculation, x * 13788, isozyme BinTx-II, sequence calculation | Bothrops insularis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bothrops insularis | isozymes BinTx-I and BinTx-II show myotoxic activity in mice skeletal muscle and contribute to the neuromuscular activity of venom, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bothrops insularis | Q8QG87 | isozyme BinTx-I; two isozymes BinTx-I and BinTx-II | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | isozymes BinTx-I and BinTx-II | Bothrops insularis | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bothrops insularis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitro-3-(octanoyloxy)benzoic acid + H2O | - |
Bothrops insularis | ? | - |
? | |
| additional information | isozymes BinTx-I and BinTx-II show myotoxic activity in mice skeletal muscle and contribute to the neuromuscular activity of venom, overview | Bothrops insularis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 13975, isozyme BinTx-I, sequence calculation, x * 13788, isozyme BinTx-II, sequence calculation | Bothrops insularis |
| More | isozymes BinTx-I and BinTx-II structure modelling, overview | Bothrops insularis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Asp49 PLA2 | - |
Bothrops insularis |
| BinTx-I | - |
Bothrops insularis |
| BinTx-II | - |
Bothrops insularis |
| PLA2 | - |
Bothrops insularis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Bothrops insularis |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Bothrops insularis | isozyme BinTx-II, sequence calculation | - |
4.49 |
| Bothrops insularis | isozyme BinTx-I, sequence calculation | - |
5.05 |
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