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Literature summary for 3.1.1.4 extracted from
- Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus (2007), Biochim. Biophys. Acta, 1770, 585-593.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Bothrops alternatus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bothrops alternatus | BaTX induces myonecrosis and edema in vivo in mice upon intramuscular or subcutaneous injection, respectively, in vitro, the enzyme rapidly lysed skeletal muscle myoblasts, and causes a potent blockade of neuromuscular transmission in young chicken biventer cervicis preparations, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bothrops alternatus | P86453 | mycotoxin II | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from venom by gel filtration | Bothrops alternatus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Bothrops alternatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitro-3-octanoyloxybenzoic acid + H2O | - |
Bothrops alternatus | ? | - |
? | |
| additional information | BaTX induces myonecrosis and edema in vivo in mice upon intramuscular or subcutaneous injection, respectively, in vitro, the enzyme rapidly lysed skeletal muscle myoblasts, and causes a potent blockade of neuromuscular transmission in young chicken biventer cervicis preparations, overview | Bothrops alternatus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 13898.71, BaTX, MALDI-TOF mass spectrometry | Bothrops alternatus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BaTX | - |
Bothrops alternatus |
| Lys49 phospholipase A2 homologue | - |
Bothrops alternatus |
| mycotoxin II | - |
Bothrops alternatus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bothrops alternatus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Bothrops alternatus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Bothrops alternatus | BaTX, sequence calculation | - |
8.63 |
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Release 2023.1 (January 2023)
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