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Literature summary for 3.1.1.4 extracted from
- Brain cytosolic phospholipase A2: localization, role, and involvement in neurological diseases (2000), Neuroscientist, 6, 169-180.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cytokines | - |
Mammalia | |
| interferons | - |
Mammalia | |
| mitogens | - |
Mammalia | |
| additional information | non-receptor-induced stimulation by oxidation, UV light or shear stress | Mammalia |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithiobis-(2-nitrobenzoic acid) | can be reversed by dithiothreitol | Bos taurus |  |
| arachidonoyl trifluoromethyl ketone | - |
Bos taurus | |
| Ca2+ | partial inhibition, isoform PLA2-H | Rattus norvegicus | |
| iodoacetamide | can be reversed by dithiothreitol | Bos taurus | |
| methyl arachidonyl fluorophosphonate | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mammalia | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | requirement, isoform PLA2-L | Rattus norvegicus | |
| additional information | no requirement for Ca2+, isoform cPLA2-alpha | Mammalia |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14000 | - |
secretory PLA2 | Rattus norvegicus |
| 61000 | - |
isoform cPLA2-gamma | Mammalia |
| 85000 | - |
isoform cPLA2-beta | Mammalia |
| 100000 | - |
isoform PLA2-L | Rattus norvegicus |
| 110000 | - |
gel filtration | Bos taurus |
| 114000 | - |
isoform cPLA2-alpha | Mammalia |
| 200000 | 500000 | isoform PLA2-H | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mammalia | involved in synaptic plasticity, generation of second messengers, axon regeneration and neurodegeneration | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mammalia | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Mammalia | - |
| astrocyte | - |
Homo sapiens | - |
| brain | - |
Mammalia | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| cerebellum | - |
Mammalia | - |
| cerebral cortex | - |
Homo sapiens | - |
| forebrain | isoform cPLA2-alpha | Rattus norvegicus | - |
| heart | - |
Mammalia | - |
| hindbrain | isoform cPLA2-alpha | Rattus norvegicus | - |
| neuron | - |
Mammalia | - |
| pancreas | - |
Mammalia | - |
| skeletal muscle | - |
Mammalia | - |
| spinal cord | isoform cPLA2-alpha | Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, 85% loss of activity in 1 week | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O | isoform cPLA2-beta and cPLA2-gamma hydrolyse this substrate at a lower rate than isoform cPLA2-alpha | Mammalia | ? | - |
? | |
| 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O | good substrate | Bos taurus | 1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid | - |
? | |
| 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O | - |
Bos taurus | 1-stearoyl-sn-glycero-3-phosphoethanolamine + arachidonic acid | - |
? | |
| 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + H2O | - |
Bos taurus | 1-stearoyl-sn-glycero-3-phosphoinositol + arachidonic acid | - |
? | |
| additional information | involved in synaptic plasticity, generation of second messengers, axon regeneration and neurodegeneration | Mammalia | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLA2-H | - |
Rattus norvegicus |
| PLA2-L | identical to cPLA2-alpha | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
complete inactivation after 1h | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Bos taurus |
| 8.3 | - |
- |
Rattus norvegicus |
| 9.5 | - |
- |
Mammalia |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.015 | - |
5,5'-dithiobis-(2-nitrobenzoic acid) | - |
Bos taurus | |
| 0.1 | - |
iodoacetamide | - |
Bos taurus | |
| 3.3 | - |
methyl arachidonyl fluorophosphonate | - |
Bos taurus | |
| 5 | - |
arachidonoyl trifluoromethyl ketone | - |
Bos taurus | |
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