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Literature summary for 3.1.1.4 extracted from

  • Edwards, S.H.; Thompson, D.; Baker, S.F.; Wood, S.P.; Wilton, D.C.
    The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism (2002), Biochemistry, 41, 15468-15476.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
wild-type and H48Q mutant Homo sapiens

Protein Variants

Protein Variants Comment Organism
H48A mutation has a serious effect on the structural integrity of the enzyme Homo sapiens
H48N 0.2% catalytic activity Homo sapiens
H48Q 2-4% catalytic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14555
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-

Reaction

Reaction Comment Organism Reaction ID
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate mechanism Homo sapiens