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Literature summary for 3.1.1.4 extracted from
- Characterisation of phospholipase A activity of b 1-Bungarotoxin from Bungarus multicinctus venom (1978), J. Biochem., 84, 1291-1300.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | prevents p-bromophenacyl bromide inactivation | Bungarus multicinctus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-bromophenacyl bromide | - |
Bungarus multicinctus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Crotalus adamanteus | |
| Ca2+ | prevents p-bromophenacyl bromide inactivation | Bungarus multicinctus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospholipids + H2O | Bungarus multicinctus | presynaptic neurotoxicity of neutral PLA2 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bungarus multicinctus | - |
- |
- |
| Crotalus adamanteus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bungarus multicinctus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Crotalus adamanteus | - |
| venom | - |
Bungarus multicinctus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5.9 | - |
substrate: phosphatidylcholine | Bungarus multicinctus |
| 12.6 | - |
substrate: phosphatidylcholine | Crotalus adamanteus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | - |
Crotalus adamanteus | 1-acylglycerophosphocholine + fatty acid | - |
? | |
| phosphatidylcholine + H2O | - |
Bungarus multicinctus | 1-acylglycerophosphocholine + fatty acid | - |
? | |
| phospholipids + H2O | presynaptic neurotoxicity of neutral PLA2 | Bungarus multicinctus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
substrate: dispersed phosphatidylcholine | Bungarus multicinctus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | - |
Bungarus multicinctus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 2 | 8 | full activity after 20 h at 37°C in acidic medium | Bungarus multicinctus |
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