Cloned (Comment) | Organism |
---|---|
into M13-vector mp8 for site directed mutagenesis, into pUEX 1 vector for tranformation of Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
M20L | according the gapped-duplex method, using amber selection | Homo sapiens |
M8L | according the gapped-duplex method, using amber selection | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-tetradecanoylaminohexanol-1-phosphocholine | competitive inhibition, R-enantiomer is a more potent inhibitor | Homo sapiens | |
2-tetradecanoylaminohexanol-1-phosphoethanolamine | competitive inhibition, R-enantiomer is a more potent inhibitor | Homo sapiens | |
2-tetradecanoylaminohexanol-1-phosphoglycol | competitive inhibition, R-enantiomer is a more potent inhibitor | Homo sapiens | |
EDTA | - |
Homo sapiens | |
EDTA | - |
Sus scrofa | |
p-bromophenacyl bromide | - |
Homo sapiens | |
p-bromophenacyl bromide | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
1,2-dioctanoyl-sn-glycero-3-phosphoglycol | - |
Homo sapiens | |
0.1 | - |
1,2-dioctanoyl-sn-glycero-3-phosphoglycol | - |
Sus scrofa | |
0.2 | - |
1,2-dioctanoyl-sn-glycero-3-phosphocholine | - |
Homo sapiens | |
0.9 | - |
1,2-dinonanoyl-sn-glycero-3-phosphocholine | - |
Homo sapiens | |
1.4 | - |
1,2-dihexanoyl-sn-glycero-3-phosphocholine | - |
Sus scrofa | |
2.4 | - |
1,2-dihexanoyl-sn-glycero-3-phosphocholine | [M8L and M20L]-loop-deleted PLA2 | Homo sapiens | |
2.8 | - |
1,2-dihexanoyl-sn-glycero-3-phosphocholine | loop deleted PLA2 | Homo sapiens | |
3 | - |
1,2-diheptanoyl-sn-glycero-3-phosphocholine | - |
Sus scrofa | |
3.2 | - |
1,2-dioctanoyl-sn-glycero-3-phosphocholine | - |
Sus scrofa | |
3.6 | - |
1,2-diheptanoyl-sn-glycero-3-phosphocholine | - |
Homo sapiens | |
4.3 | - |
1,2-dihexanoyl-sn-glycero-3-phosphocholine | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Ca2+ | - |
Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
14000 | - |
- |
Sus scrofa |
14000 | - |
heparin-sepharose affinity chromatography, SDS-PAGE after digestion with thrombin, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipids + H2O | Homo sapiens | influence on platelet aggregation | ? | - |
? | |
phospholipids + H2O | Homo sapiens | inflammatory diseases | ? | - |
? | |
phospholipids + H2O | Homo sapiens | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? | |
phospholipids + H2O | Sus scrofa | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Naja melanoleuca | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ion exchange chromatography | Homo sapiens |
Renatured (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
pancreas | - |
Sus scrofa | - |
platelet | - |
Homo sapiens | - |
venom | - |
Naja melanoleuca | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
25 | - |
substrate: dioleolyl-sn-phosphatidylcholine | Homo sapiens |
29 | - |
substrate: 1,2-dipalmitoyl-phosphatidylcholine | Sus scrofa |
30 | - |
substrate: 1,2-dipalmitoyl-phosphatidylcholine | Homo sapiens |
57 | - |
substrate: dimyristoyl-sn-phosphatidylcholine | Homo sapiens |
68 | - |
substrate: dimyristoyl-sn-phosphatidylcholine | Sus scrofa |
80 | - |
substrate: 1,2-dilaureoyl-sn-glycero-3-phosphocholine | Sus scrofa |
81 | - |
substrate: 1,2-didecanoyl-sn-glycero-3-phosphocholine | Sus scrofa |
118 | - |
substrate: 1,2-didecanoyl-sn-glycero-3-phosphocholine | Homo sapiens |
124 | - |
substrate: 1,2-dilaureoyl-sn-glycero-3-phosphocholine | Homo sapiens |
125 | - |
substrate: 1,2-dinonanoyl-sn-glycero-3-phosphocholine | Sus scrofa |
155 | - |
substrate: dioleolyl-sn-phosphatidylethanolamine | Homo sapiens |
162 | - |
substrate: 1,2-dioctanoyl-sn-glycero-3-phosphocholine | Sus scrofa |
171 | - |
substrate: 1,2-dinonanoyl-sn-glycero-3-phosphocholine | Homo sapiens |
172 | - |
substrate: 1,2-dioctanoyl-sn-glycero-3-phosphocholine | Homo sapiens |
208 | - |
substrate: dioleolyl phosphatidylglycerol | Homo sapiens |
210 | - |
substrate: dioleolyl-sn-phosphatidylethanolamine | Naja melanoleuca |
295 | - |
substrate: dioleolyl-sn-phosphatidylethanolamine | Sus scrofa |
320 | - |
substrate: dioleolyl-sn-phosphatidylcholine | Sus scrofa |
410 | - |
substrate: dioleolyl-sn-phosphatidylcholine | Naja melanoleuca |
530 | - |
substrate: dioleolyl phosphatidylglycerol | Naja melanoleuca |
615 | - |
substrate: dioleolyl phosphatidylglycerol | Sus scrofa |
750 | - |
substrate: dimyristoyl-sn-phosphatidylcholine | Naja melanoleuca |
1220 | - |
substrate: 1,2-dioctanoyl-sn-glycero-3-phosphoglycol | Naja melanoleuca |
3235 | - |
substrate: 1,2-didecanoyl-sn-glycero-3-phosphocholine | Naja melanoleuca |
4650 | - |
substrate: 1,2-dilaureoyl-sn-glycero-3-phosphocholine | Naja melanoleuca |
8870 | - |
substrate: 1,2-dinonanoyl-sn-glycero-3-phosphocholine | Naja melanoleuca |
9300 | - |
substrate: 1,2-dioctanoyl-sn-glycero-3-phosphoglycol | Homo sapiens |
11400 | - |
substrate: 1,2-dioctanoyl-sn-glycero-3-phosphocholine | Naja melanoleuca |
16000 | - |
substrate: 1,2-dioctanoyl-sn-glycero-3-phosphoglycol | Sus scrofa |
Storage Stability | Organism |
---|---|
room temperature, in presence or absence of Ca2+, pH ranging from 4.5 to 9.0, after 7 days more than 95% of the activity remains | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Sus scrofa | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Naja melanoleuca | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
1,2-didodecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
1,2-didodecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Sus scrofa | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
1,2-didodecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Naja melanoleuca | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O | - |
Homo sapiens | 1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate | - |
? | |
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O | - |
Sus scrofa | 1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate | - |
? | |
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O | - |
Naja melanoleuca | 1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate | - |
? | |
1,2-diheptanoyl-sn-glycero-3-sulfate + H2O | - |
Homo sapiens | 1-heptanoyl-sn-glycero-3-sulfate + heptanoate | - |
? | |
1,2-diheptanoyl-sn-glycero-3-sulfate + H2O | - |
Sus scrofa | 1-heptanoyl-sn-glycero-3-sulfate + heptanoate | - |
? | |
1,2-diheptanoyl-sn-glycero-3-sulfate + H2O | - |
Naja melanoleuca | 1-heptanoyl-sn-glycero-3-sulfate + heptanoate | - |
? | |
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate | - |
? | |
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O | - |
Sus scrofa | 1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate | - |
? | |
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O | - |
Naja melanoleuca | 1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate | - |
? | |
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-lauroyl-sn-glycero-3-phosphocholine + laureate | - |
? | |
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O | - |
Sus scrofa | 1-lauroyl-sn-glycero-3-phosphocholine + laureate | - |
? | |
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O | - |
Naja melanoleuca | 1-lauroyl-sn-glycero-3-phosphocholine + laureate | - |
? | |
1,2-dimyristoyl-sn-phosphatidylcholine + H2O | - |
Homo sapiens | 1-myristoyl-phosphorylcholine + myristic acid | - |
? | |
1,2-dimyristoyl-sn-phosphatidylcholine + H2O | - |
Sus scrofa | 1-myristoyl-phosphorylcholine + myristic acid | - |
? | |
1,2-dimyristoyl-sn-phosphatidylcholine + H2O | - |
Naja melanoleuca | 1-myristoyl-phosphorylcholine + myristic acid | - |
? | |
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-nonanoyl-sn-glycero-3-phosphocholine + nonanoate | - |
? | |
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O | - |
Sus scrofa | 1-nonanoyl-sn-glycero-3-phosphocholine + nonanoate | - |
? | |
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O | - |
Naja melanoleuca | 1-nonanoyl-sn-glycero-3-phosphocholine + nonanoate | - |
? | |
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-octanoyl-sn-glycero-3-phosphocholine + octanoate | - |
? | |
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O | - |
Sus scrofa | 1-octanoyl-sn-glycero-3-phosphocholine + octanoate | - |
? | |
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O | - |
Naja melanoleuca | 1-octanoyl-sn-glycero-3-phosphocholine + octanoate | - |
? | |
1,2-dioctanoyl-sn-glycero-3-phosphoglycol + H2O | - |
Homo sapiens | 1-octanoyl-sn-glycero-3-phosphoglycol + octanoate | - |
? | |
1,2-dioctanoyl-sn-glycero-3-phosphoglycol + H2O | - |
Sus scrofa | 1-octanoyl-sn-glycero-3-phosphoglycol + octanoate | - |
? | |
1,2-dioctanoyl-sn-glycero-3-phosphoglycol + H2O | - |
Naja melanoleuca | 1-octanoyl-sn-glycero-3-phosphoglycol + octanoate | - |
? | |
1,2-dioleoyl-sn-phosphatidylcholine + H2O | - |
Homo sapiens | 1-oleoyl-sn-phosphatidylcholine + oleate | - |
? | |
1,2-dioleoyl-sn-phosphatidylcholine + H2O | - |
Sus scrofa | 1-oleoyl-sn-phosphatidylcholine + oleate | - |
? | |
1,2-dioleoyl-sn-phosphatidylcholine + H2O | - |
Naja melanoleuca | 1-oleoyl-sn-phosphatidylcholine + oleate | - |
? | |
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O | - |
Homo sapiens | 1-oleoyl-sn-phosphatidylethanolamine + oleic acid | - |
? | |
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O | - |
Sus scrofa | 1-oleoyl-sn-phosphatidylethanolamine + oleic acid | - |
? | |
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O | - |
Naja melanoleuca | 1-oleoyl-sn-phosphatidylethanolamine + oleic acid | - |
? | |
1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Sus scrofa | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Naja melanoleuca | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O | - |
Homo sapiens | 1-acyl-3-phosphoethanolamine + linolic acid | - |
? | |
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O | - |
Sus scrofa | 1-acyl-3-phosphoethanolamine + linolic acid | - |
? | |
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O | - |
Naja melanoleuca | 1-acyl-3-phosphoethanolamine + linolic acid | - |
? | |
dioleoyl phosphatidylglycerol + H2O | - |
Homo sapiens | ? | - |
? | |
dioleoyl phosphatidylglycerol + H2O | - |
Sus scrofa | ? | - |
? | |
dioleoyl phosphatidylglycerol + H2O | - |
Naja melanoleuca | ? | - |
? | |
phospholipids + H2O | influence on platelet aggregation | Homo sapiens | ? | - |
? | |
phospholipids + H2O | inflammatory diseases | Homo sapiens | ? | - |
? | |
phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Homo sapiens | ? | - |
? | |
phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Sus scrofa | ? | - |
? | |
rac-1,2-dihexanoyldithiopropyl-3-phosphocholine + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Homo sapiens |
monomer | - |
Sus scrofa |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
after 7 days more than 95% of the activity remains, in presence or absence of Ca2+, pH ranging from 4.5 to 9.0 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |
8 | - |
- |
Sus scrofa |