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Literature summary for 3.1.1.4 extracted from
- Purification and characterization of nuclear alkaline phospholipase A2 in rat ascites hepatoma cells (1996), FEBS Lett., 394, 55-60.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anti-peptide antibody | group II PLA2-antibody | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
arachidonyl phosphatidylethanolamine | neutral nuclear PLA2 | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | in chromatin rich fraction | Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Rattus norvegicus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospholipids + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| column chromatography, immunoadsorbent column containing group II PLA2-antibodies, 735fold | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatoma ascites cell line | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dioleoyl-sn-phosphatidylethanolamine + H2O | - |
Rattus norvegicus | 1-oleoyl-sn-phosphatidylethanolamine + oleic acid | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylserine + H2O | - |
Rattus norvegicus | 1-palmitoyl-sn-phosphatidylserine + palmitic acid | - |
? | |
| 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O | - |
Rattus norvegicus | 1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid | - |
? | |
| 1-acyl-2-arachidonoyl-sn-glycerophosphoethanolamine + H2O | - |
Rattus norvegicus | 1-acyl-sn-glycerophosphoethanolamine + arachidonic acid | - |
? | |
| 1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O | - |
Rattus norvegicus | 1-palmitoyl-glycerophosphorylethanolamine + linolic acid | - |
? | |
| 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + H2O | - |
Rattus norvegicus | 1-stearoyl-sn-glycero-3-phosphoinositol + arachidonic acid | - |
? | |
| 1-stearoyl-2-arachidonoylphosphatidylcholine + H2O | - |
Rattus norvegicus | 1-stearoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
| arachidonyl phosphatidylethanolamine + H2O | - |
Rattus norvegicus | glycerophosphoethanolamine + arachidonic acid | - |
? | |
| phosphatidylethanolamine + H2O | - |
Rattus norvegicus | 1-acylglycerophosphorylethanolamine + fatty acid | - |
? | |
| phospholipids + H2O | - |
Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | 10 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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