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Literature summary for 3.1.1.4 extracted from
- Characterization of plasmalogen-selective phospholipase A2 from bovine brain (1996), Adv. Exp. Med. Biol., 416, 309-313.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | plasmalogen-specific PLA2, activating | Homo sapiens |  |
| Triton X-100 | plasmalogen-specific PLA2, activating | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag+ | plasmalogen-specific PLA2 | Bos taurus | |
| ATP | plasmalogen-specific PLA2 | Bos taurus | |
| bromoenol lactone | plasmalogen-specific PLA2, suicide inhibitor, IC50 30nM | Homo sapiens | |
| chondroitin sulfate | plasmalogen-specific PLA2 | Bos taurus | |
| citrate | plasmalogen-specific PLA2 | Bos taurus | |
| Cowper's gland mucin | plasmalogen-specific PLA2 | Bos taurus | |
| DTNB | plasmalogen-specific PLA2 | Bos taurus | |
| DTNB | plasmalogen-specific PLA2 | Homo sapiens | |
| Fe3+ | plasmalogen-specific PLA2 | Bos taurus | |
| fetuin | plasmalogen-specific PLA2 | Bos taurus | |
| ganglioside GM1 | plasmalogen-specific PLA2 | Bos taurus | |
| ganglioside GM3 | plasmalogen-specific PLA2 | Bos taurus | |
| heparan sulfate | plasmalogen-specific PLA2 | Bos taurus | |
| heparin | plasmalogen-specific PLA2 | Bos taurus | |
| Hg2+ | plasmalogen-specific PLA2 | Bos taurus | |
| hyaluronic acid | plasmalogen-specific PLA2 | Bos taurus | |
| iodoacetate | plasmalogen-specific PLA2 | Bos taurus | |
| mucin | plasmalogen-specific PLA2 | Bos taurus | |
| N-acetylneuraminic acid | plasmalogen-specific PLA2 | Bos taurus | |
| N-ethylmaleimide | plasmalogen-specific PLA2 | Bos taurus | |
| octylglucoside | plasmalogen-specific PLA2 | Bos taurus | |
| phosphate | plasmalogen-specific PLA2 | Bos taurus | |
| sodium deoxycholate | plasmalogen-specific PLA2 | Bos taurus | |
| sodium deoxycholate | - |
Homo sapiens | |
| sulfate | plasmalogen-specific PLA2 | Bos taurus | |
| taurocholate | plasmalogen-specific PLA2 | Bos taurus | |
| Triton X-100 | plasmalogen-specific PLA2 | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.004 | - |
choline plasmalogen | - |
Homo sapiens | |
| 0.04 | - |
ethanolamine plasmalogen | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Bos taurus | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
- |
Bos taurus |
| 40000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospholipids + H2O | Homo sapiens | influence on platelet aggregation | ? | - |
? | |
| phospholipids + H2O | Bos taurus | influence on platelet aggregation | ? | - |
? | |
| phospholipids + H2O | Homo sapiens | eicosanoids | ? | - |
? | |
| phospholipids + H2O | Bos taurus | eicosanoids | ? | - |
? | |
| phospholipids + H2O | Homo sapiens | inflammatory diseases | ? | - |
? | |
| phospholipids + H2O | Bos taurus | inflammatory diseases | ? | - |
? | |
| plasmalogen + H2O | Bos taurus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Bos taurus | - |
| heart | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choline plasmalogen + H2O | - |
Homo sapiens | lysoplasmalogen + fatty acid | - |
? | |
| ethanolamine plasmalogen + H2O | - |
Bos taurus | lysoplasmalogen + fatty acid | - |
? | |
| phospholipids + H2O | influence on platelet aggregation | Homo sapiens | ? | - |
? | |
| phospholipids + H2O | influence on platelet aggregation | Bos taurus | ? | - |
? | |
| phospholipids + H2O | eicosanoids | Homo sapiens | ? | - |
? | |
| phospholipids + H2O | eicosanoids | Bos taurus | ? | - |
? | |
| phospholipids + H2O | inflammatory diseases | Homo sapiens | ? | - |
? | |
| phospholipids + H2O | inflammatory diseases | Bos taurus | ? | - |
? | |
| plasmalogen + H2O | - |
Bos taurus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Homo sapiens |
| 7.4 | - |
- |
Bos taurus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
plasmalogen-specific PLA2, suicide inhibitor, IC50 30nM | Homo sapiens | bromoenol lactone | |
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