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Literature summary for 3.1.1.34 extracted from

  • Heerwagen, M.J.R.; Gumina, D.L.; Hernandez, T.L.; Van Pelt, R.E.; Kramer, A.W.; Janssen, R.C.; Jensen, D.R.; Powell, T.L.; Friedman, J.E.; Winn, V.D.; Barbour, L.A.
    Placental lipoprotein lipase activity is positively associated with newborn adiposity (2018), Placenta, 64, 53-60 .
    View publication on PubMed
Search for more literature for 3.1.1.34

Cloned(Commentary)

Cloned (Comment) Organism
gene Lpl, quantitative real-time PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Homo sapiens
-
 diacylglycerol + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P06858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Homo sapiens
-
additional information adipose tissue LPL activity is markedly higher than placental LPL activity. In pregnant women, adipose tissue LPL activity, which hydrolyzes triglycerides to free fatty acids for uptake into maternal fat, is not correlated with body weight or newborn adiposity Homo sapiens
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
triacylglycerol + H2O
-
 Homo sapiens diacylglycerol + a carboxylate
-
 ?
triacylglycerol + H2O a 14C-triolein phosphatidylcholine-stabilized substrate containing ApoC2 is used for in vitro enzyme activity assays Homo sapiens diacylglycerol + a carboxylate
-
 ?

Synonyms

Synonyms Comment Organism
adipose tissue LPL
-
 Homo sapiens
LPL
-
 Homo sapiens
placental lipoprotein lipase
-
 Homo sapiens
pLPL
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function placental lipoprotein lipase activity is positively associated with newborn adiposity. Placental lipoprotein lipase (pLPL) hydrolyzes triglycerides (TG), both dietary chylomicron TG (CM-TG) and very-low density lipoprotein TG (VLDL-TG), to free fatty acids (FFA). This may promote fetal fat accretion by increasing the available FFA pool for placental uptake. pLPL activity, but not maternal adipose tissue LPL activity, is associated with newborn adiposity and higher maternal TG. Placental LPL activity is positively correlated with birthweight and newborn percent body fat, but maternal adipose tissue LPL is not. Maternal TG and BMI are not correlated with pLPL. pLPL gene expression, while modestly correlated with enzymatic activity, is not correlated with newborn adiposity. Placental lipase regulation and the role of pLPL in pregnancies, overview Homo sapiens