Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apoC-II | activation of LPL | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiopoietin-like protein 3 | ANGPTL3 causes reduction of the activity of LPL via a two-step mechanism | Homo sapiens | |
angiopoietin-like protein 4 | ANGPTL4 causes reduction of the activity of LPL via a two-step mechanism. The N-terminal coiled-coil domain of human ANGPTL4, residues 26-184, is expressed in Escherichia coli and purified | Homo sapiens | |
apoC-III | inhibits the enzyme's lipolysis activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | initial rates and kinetics for complete hydrolysis of plasma lipids in postheparin plasma | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | Homo sapiens | lipoproteins with high triglyceride | diacylglycerol + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P06858 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Homo sapiens | - |
blood plasma | - |
Homo sapiens | - |
endothelium | - |
Homo sapiens | - |
additional information | enzyme LPL is produced and secreted from parenchymal cells like adipocytes and myocytes for transport to the luminal side of the endothelium via interaction with the glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1) | Homo sapiens | - |
myocyte | - |
Homo sapiens | - |
parenchyma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | lipoproteins with high triglyceride | Homo sapiens | diacylglycerol + a carboxylate | - |
? | |
triacylglycerol + H2O | the lipase substrate used is plasma or VLDL with or without added ligands, enzyme source is postheparin plasma, lipoproteins with high triglyceride | Homo sapiens | diacylglycerol + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LPL | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme ligand interaction analysis by isothermal titration calorimetry (ITC) using human plasma as substrate. ITC can be used for quantitative measurements of LPL activity and interactions under in vivo-like conditions, for comparisons of the properties of plasma samples from patients and control subjects as substrates for LPL, as well as for testing of drug candidates, method evaluation, overview | Homo sapiens |
physiological function | the hydrolytic breakdown of plasma triglycerides by LPL at the capillary endothelium is a crucial event that contributes to control of the levels of triglycerides in plasma. LPL hydrolyzes triglycerides in plasma lipoproteins through a complex regulation mechanism | Homo sapiens |