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Literature summary for 3.1.1.32 extracted from

  • Nassogne, M.C.; Lizarraga, C.; N'Kuli, F.; Van Bambeke, F.; Van Binst, R.; Wallemacq, P.; Tulkens, P.M.; Mingeot-Leclercq, M.P.; Levade, T.; Courtoy, P.J.
    Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1 (2004), Toxicol. Appl. Pharmacol., 194, 101-110.
    View publication on PubMed

Application

Application Comment Organism
medicine acidotropic accumulation of cocaine in lysosomes inhibits acid phospholipase A1 and inactivates acid sphingomyelinase, inducing a mixed lysosomal lipidosis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cocaine 10 mM, below 10% residual activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Rattus norvegicus 5764
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture fibroblast Rattus norvegicus
-
fibroblast cultured cells Rattus norvegicus
-