Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CGI-58 | ATGL binds to CGI-58, and ATGL activity is strongly stimulated, about 20fold, by an activator protein annotated as alpha/beta hydrolase domain containing protein 5, ABHD5, also known as comparative gene identification-58, CGI-58. Phosphorylation of perilipin interferes with CGI-58 interaction in vitro and in vivo | Mus musculus | |
CGI-58 | ATGL binds to CGI-58, and ATGL activity is strongly stimulated, about 5fold, by an activator protein annotated as alpha/beta hydrolase domain containing protein 5, ABHD5, also known as comparative gene identification-58, CGI-58. Phosphorylation of perilipin interferes with CGI-58 interaction in vitro and in vivo | Homo sapiens | |
perilipin A | phosphorylation of perilipin specifically at serine 517 by protein kinase A is essential for ATGL activation, overview | Mus musculus | |
perilipin A | phosphorylation of perilipin specifically at serine 517 by protein kinase A is essential for ATGL activation, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | ATGL-deficiency as autosomal recessive disorder, named neutral lipid storage disease with myopathy, NLSDM, causes systemic triacylglyceride accumulation, patients invariably suffer from myopathy and accumulate TG in leucocytes phenotypes, overview | Homo sapiens |
additional information | ATGL-deficiency decreases the release of fatty acids from white adipose tissue by about 70% in response to isoproterenol treatment, and this decreased lipolytic rate results in substantially reduced plasma fatty acid levels in ATGL-KO mice. Moreover, ATGL deficient mice are extremely cold-sensitive. Upon fasting, they reduce their oxygen consumption and drop their body temperature, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerided is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview | ? | - |
? | |
additional information | Mus musculus | ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerides is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
adipocyte | - |
Homo sapiens | - |
adipose tissue | high expression level of ATGL | Mus musculus | - |
adipose tissue | high expression level of ATGL | Homo sapiens | - |
cardiac muscle | - |
Mus musculus | - |
cardiac muscle | - |
Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
macrophage | - |
Mus musculus | - |
macrophage | - |
Homo sapiens | - |
skeletal muscle | ATGL is predominantly expressed in type I fibers | Homo sapiens | - |
skeletal muscle | in type I fibers | Mus musculus | - |
testis | - |
Mus musculus | - |
testis | - |
Homo sapiens | - |
white adipose tissue | - |
Mus musculus | - |
white adipose tissue | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerided is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview | Homo sapiens | ? | - |
? | |
additional information | ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerides is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview | Mus musculus | ? | - |
? | |
additional information | ATGLalso possesses phospholipase and transacylase activity | Mus musculus | ? | - |
? | |
additional information | ATGLalso possesses phospholipase and transacylase activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adipose triglyceride lipase | - |
Mus musculus |
adipose triglyceride lipase | - |
Homo sapiens |
ATGL | - |
Mus musculus |
ATGL | - |
Homo sapiens |
desnutrin | - |
Mus musculus |
desnutrin | - |
Homo sapiens |
phospholipase A2xi | - |
Homo sapiens |
TG hydrolase | - |
Mus musculus |
TG hydrolase | - |
Homo sapiens |
TG lipase | - |
Mus musculus |
TG lipase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | mRNA and protein levels are reduced in obese patients with insulin resistance | down |
General Information | Comment | Organism |
---|---|---|
malfunction | ATGL-deficiency decreases the release of fatty acids from white adipose tissue by about 70% in response to isoproterenol treatment, and this decreased lipolytic rate results in substantially reduced plasma fatty acid levels in ATGL-KO mice. Moreover, ATGL deficient mice are extremely cold-sensitive. Upon fasting, they reduce their oxygen consumption and drop their body temperature, phenotype, overview | Mus musculus |
metabolism | ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. ATGL is important in the lipolysis, the coordinated catabolism of triacylglycerol stored in cellular lipid droplets, providing fatty acids, di-, and monoglycerides, besides the hormone sensitive lipase, and the lipid droplet binding proteins, perilipin, adipophilin, and Tip47, detailed pathway overview | Mus musculus |
metabolism | ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. ATGL is important in the lipolysis, the coordinated catabolism of triacylglycerol stored in cellular lipid droplets, providing fatty acids, di-, and monoglycerides, besides the hormone sensitive lipase, and the lipid droplet binding proteins, perilipin, adipophilin, and Tip47, detailed pathway overview | Homo sapiens |