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Literature summary for 3.1.1.3 extracted from

  • Zimmermann, R.; Lass, A.; Haemmerle, G.; Zechner, R.
    Fate of fat: the role of adipose triglyceride lipase in lipolysis (2009), Biochim. Biophys. Acta, 1791, 494-500.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CGI-58 ATGL binds to CGI-58, and ATGL activity is strongly stimulated, about 20fold, by an activator protein annotated as alpha/beta hydrolase domain containing protein 5, ABHD5, also known as comparative gene identification-58, CGI-58. Phosphorylation of perilipin interferes with CGI-58 interaction in vitro and in vivo Mus musculus
CGI-58 ATGL binds to CGI-58, and ATGL activity is strongly stimulated, about 5fold, by an activator protein annotated as alpha/beta hydrolase domain containing protein 5, ABHD5, also known as comparative gene identification-58, CGI-58. Phosphorylation of perilipin interferes with CGI-58 interaction in vitro and in vivo Homo sapiens
perilipin A phosphorylation of perilipin specifically at serine 517 by protein kinase A is essential for ATGL activation, overview Mus musculus
perilipin A phosphorylation of perilipin specifically at serine 517 by protein kinase A is essential for ATGL activation, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ATGL-deficiency as autosomal recessive disorder, named neutral lipid storage disease with myopathy, NLSDM, causes systemic triacylglyceride accumulation, patients invariably suffer from myopathy and accumulate TG in leucocytes phenotypes, overview Homo sapiens
additional information ATGL-deficiency decreases the release of fatty acids from white adipose tissue by about 70% in response to isoproterenol treatment, and this decreased lipolytic rate results in substantially reduced plasma fatty acid levels in ATGL-KO mice. Moreover, ATGL deficient mice are extremely cold-sensitive. Upon fasting, they reduce their oxygen consumption and drop their body temperature, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerided is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview ?
-
?
additional information Mus musculus ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerides is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-
adipocyte
-
Mus musculus
-
adipocyte
-
Homo sapiens
-
adipose tissue high expression level of ATGL Mus musculus
-
adipose tissue high expression level of ATGL Homo sapiens
-
cardiac muscle
-
Mus musculus
-
cardiac muscle
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
macrophage
-
Mus musculus
-
macrophage
-
Homo sapiens
-
skeletal muscle ATGL is predominantly expressed in type I fibers Homo sapiens
-
skeletal muscle in type I fibers Mus musculus
-
testis
-
Mus musculus
-
testis
-
Homo sapiens
-
white adipose tissue
-
Mus musculus
-
white adipose tissue
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerided is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview Homo sapiens ?
-
?
additional information ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. The specific activity against triacylglycerides is more than 10fold higher than against diacylglyceride, and the enzyme shows essentially no hydrolytic activity when other lipid substrates are used such as cholesteryl esters or retinyl esters. Molecular mechanisms that regulate ATGL activity, detailed overview Mus musculus ?
-
?
additional information ATGLalso possesses phospholipase and transacylase activity Mus musculus ?
-
?
additional information ATGLalso possesses phospholipase and transacylase activity Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
adipose triglyceride lipase
-
Mus musculus
adipose triglyceride lipase
-
Homo sapiens
ATGL
-
Mus musculus
ATGL
-
Homo sapiens
desnutrin
-
Mus musculus
desnutrin
-
Homo sapiens
phospholipase A2xi
-
Homo sapiens
TG hydrolase
-
Mus musculus
TG hydrolase
-
Homo sapiens
TG lipase
-
Mus musculus
TG lipase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens mRNA and protein levels are reduced in obese patients with insulin resistance down

General Information

General Information Comment Organism
malfunction ATGL-deficiency decreases the release of fatty acids from white adipose tissue by about 70% in response to isoproterenol treatment, and this decreased lipolytic rate results in substantially reduced plasma fatty acid levels in ATGL-KO mice. Moreover, ATGL deficient mice are extremely cold-sensitive. Upon fasting, they reduce their oxygen consumption and drop their body temperature, phenotype, overview Mus musculus
metabolism ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. ATGL is important in the lipolysis, the coordinated catabolism of triacylglycerol stored in cellular lipid droplets, providing fatty acids, di-, and monoglycerides, besides the hormone sensitive lipase, and the lipid droplet binding proteins, perilipin, adipophilin, and Tip47, detailed pathway overview Mus musculus
metabolism ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. ATGL is important in the lipolysis, the coordinated catabolism of triacylglycerol stored in cellular lipid droplets, providing fatty acids, di-, and monoglycerides, besides the hormone sensitive lipase, and the lipid droplet binding proteins, perilipin, adipophilin, and Tip47, detailed pathway overview Homo sapiens