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Literature summary for 3.1.1.3 extracted from

  • Watt, M.J.
    Triglyceride lipases alter fuel metabolism and mitochondrial gene expression (2009), Appl. Physiol. Nutr. Metab., 34, 340-347.
    View publication on PubMed
Search for more literature for 3.1.1.3

Activating Compound

Activating Compound Comment Organism Structure
CGI-58 a ATGL activator protein Mus musculus
CGI-58 a ATGL activator protein, located on the surface of lipid droplets, requires interaction with perilipin A for activation of ATGL. After beta-adrenergic stimulation, CGI-58 disperses into the cytoplasm within min, which appears to be due to phosphorylation of perilipin A. Phosphorylation at Ser517 of perilipin A is mandatory for stimulated lipolysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ATGL-/- mice are obese, exhibit impaired thermogenesis, oxidize more carbohydrate, and die prematurely due to cardiac dysfunction Homo sapiens
additional information ATGL-/- mice are obese, exhibit impaired thermogenesis, oxidize more carbohydrate, and die prematurely due to cardiac dysfunction. ATGL-/- mice developed heart failure due to myocardial fibrosis and a mechanical contraction defect, thereby reducing their life span. HSL-/- mice show defective beta-adrenergic stimulated lipolysis, protection against high-fat diet-induced obesity, and possible impairments in insulin secretion. Phenotypes, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm mainly Mus musculus 5737
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cytoplasm mainly Homo sapiens 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens adipose TG lipase, ATGL, and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview ?
-
 ?
additional information Mus musculus ATGL and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue ATGL is the predominant TG lipase in adipose tissue Mus musculus
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adipose tissue ATGL is the predominant TG lipase in adipose tissue Homo sapiens
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skeletal muscle
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 Mus musculus
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skeletal muscle
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information adipose TG lipase, ATGL, and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview Homo sapiens ?
-
 ?
additional information ATGL and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
adipose TG lipase
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 Mus musculus
adipose TG lipase
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 Homo sapiens
ATGL
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 Mus musculus
ATGL
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 Homo sapiens
hormone sensitive lipase
-
 Homo sapiens
HSL
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function adipose TG lipase, ATGL, is the predominant TG lipase in adipose tissue and an important regulator of triacyglycerol degradation in skeletal muscle Mus musculus
physiological function ATGL is a TG hydrolase in skeletal muscle that alters fat metabolism. Adipose TG lipase, ATGL, is the predominant TG lipase in adipose tissue and an important regulator of triacyglycerol degradation in skeletal muscle, overview. ATGL might also possess acylglycerol transacylase activity. Regulation of ATGL transacylation and lipase activities by undefined mechanisms can alter the metabolic balance within adipocytes, from anabolic (i.e. high transacylase activity) to catabolic (i.e. high lipase activity) situations, and thereby alter substrate delivery to peripheral tissues Homo sapiens