Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.25 extracted from

  • Fishbein, W.N.; Bessman, S.P.
    Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase (1966), J. Biol. Chem., 241, 4835-4841.
    View publication on PubMed

General Stability

General Stability Organism
freezing destroys 30-50% of the activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Homo sapiens
EDTA
-
Rattus norvegicus
eserine weak inhibition Rattus norvegicus
ethanol 6%, 85% inhibition Rattus norvegicus
ethyl beta-hydroxybutyrate weak inhibition Rattus norvegicus
neostigmine
-
Rattus norvegicus
PCMB 0.1 mM Homo sapiens
PCMB 0.1 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
blood plasma
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-butyrolactone + H2O
-
Homo sapiens gamma-hydroxybutyrate
-
r
gamma-butyrolactone + H2O
-
Rattus norvegicus gamma-hydroxybutyrate
-
r
gamma-caprolactone + H2O
-
Homo sapiens gamma-hydroxycaproate
-
r
gamma-caprolactone + H2O
-
Rattus norvegicus gamma-hydroxycaproate
-
r
gamma-octalactone + H2O
-
Homo sapiens 4-hydroxyoctanoate
-
r
gamma-octalactone + H2O
-
Rattus norvegicus 4-hydroxyoctanoate
-
r
gamma-valerolactone + H2O
-
Homo sapiens gamma-hydroxyvalerate
-
r
gamma-valerolactone + H2O
-
Rattus norvegicus gamma-hydroxyvalerate
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
32
-
-
Homo sapiens
32
-
-
Rattus norvegicus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
15 37 15°C: about 65% of maximal activity, 37°C: about 90% of maximal activity Homo sapiens
15 37 15°C: about 65% of maximal activity, 37°C: about 90% of maximal activity Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
90
-
4 min, complete loss of activity Homo sapiens
90
-
4 min, complete loss of activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
lactonization Homo sapiens
6
-
lactonization Rattus norvegicus
8.6
-
hydrolysis Homo sapiens
8.6
-
hydrolysis Rattus norvegicus