Literature summary for 3.1.1.23 extracted from

Karageorgos, I.; Wales, T.E.; Janero, D.R.; Zvonok, N.; Vemuri, V.K.; Engen, J.R.; Makriyannis, A.
Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study (2013), Biochemistry, 52, 5016-5026.

Search for more literature for 3.1.1.23

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
AM6580	irreversible inhibitor, i.e. [4-(9H-fluoren-9-yl)-piperazin-1-yl][1,2,3]triazolo[4,5-b]pyridin-1-ylmethanone	Homo sapiens
AM6701	slowly reversible inhibition, i.e. 5-((biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetra-zole-2-carboxamide	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.044	-	2-arachidonoylglycerol	pH and temperature not specified in the publication	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
34178	-	1 * 34178, calculated from amino acid sequence	Homo sapiens
35000	-	1 * 35000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
TALON metal affinity resin column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-arachidonoylglycerol + H2O	-	Homo sapiens	glycerol + arachidonic acid	-	?

Subunits

Subunits	Comment	Organism
monomer	1 * 35000, SDS-PAGE	Homo sapiens
monomer	1 * 34178, calculated from amino acid sequence	Homo sapiens

Synonyms

Synonyms	Comment	Organism
MGL	-	Homo sapiens
monoacylglycerol lipase	-	Homo sapiens

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Release 2023.1 (January 2023)