Literature summary for 3.1.1.23 extracted from

Bertrand, T.; Auge, F.; Houtmann, J.; Rak, A.; Vallee, F.; Mikol, V.; Berne, P.; Michot, N.; Cheuret, D.; Hoornaert, C.; Mathieu, M.
Structural basis for human monoglyceride lipase inhibition (2010), J. Mol. Biol., 396, 663-673.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
apoenzyme alone or in complex with inhibitor SAR629, in 50 mM MES (pH 6.0) and 40% (v/v) 2-methyl-pentane-2,4-diol, at 4°C	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
JZL184	-	Homo sapiens
N-arachidonoylmaleimide	-	Homo sapiens
SAR629	substrate mimic	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-Sepharose column chromatography and Superdex 75 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-arachidonoylglycerol + H2O	-	Homo sapiens	glycerol + arachidonic acid	-	?

Synonyms

Synonyms	Comment	Organism
MGL	-	Homo sapiens
monoglyceride lipase	-	Homo sapiens

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Release 2023.1 (January 2023)