Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JZL184 | irreversible inhibitor | Homo sapiens | |
N-arachidonoyl dopamine | - |
Homo sapiens | |
troglitazone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MUM-2B cell | - |
Homo sapiens | - |
MUM-2C cell | - |
Homo sapiens | - |
OVCAR-3 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MAGL | - |
Homo sapiens |
monoacylglycerol lipase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | monoacylglycerol lipase is highly expressed in aggressive human cancer cells and primary tumors | up |
General Information | Comment | Organism |
---|---|---|
malfunction | disruption of MAGL expression and activity impairs cancer pathogenicity. impairments in MAGL-dependent tumor growth are rescued by a high-fat diet, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity | Homo sapiens |
physiological function | monoacylglycerol lipase (MAGL) regulates a fatty acid network that promotes cancer pathogenesis. MAGL, through hydrolysis of monoacylglycerols, controls free fatty acid levels in cancer cells | Homo sapiens |