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Literature summary for 3.1.1.23 extracted from

  • Guindon, J.; Guijarro, A.; Piomelli, D.; Hohmann, A.G.
    Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain (2011), Br. J. Pharmacol., 163, 1464-1478.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine MGL represents a target for the treatment of inflammatory pain Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
JZL184 irreversible inhibitor Rattus norvegicus
URB602 reversible inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
Rattus norvegicus glycerol + arachidonic acid
-
?

Synonyms

Synonyms Comment Organism
MGL
-
Rattus norvegicus
monoacylglycerol lipase
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction MGL inhibitors suppress formalin-induced pain through peripheral cannabinoid receptor 1 and cannabinoid receptor 2 receptor mechanisms. MGL inhibition increases paw skin 2-arachidonoylglycerol accumulation to mediate these effects Rattus norvegicus