Application | Comment | Organism |
---|---|---|
medicine | MGL represents a target for the treatment of inflammatory pain | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JZL184 | irreversible inhibitor | Rattus norvegicus | |
URB602 | reversible inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-arachidonoylglycerol + H2O | - |
Rattus norvegicus | glycerol + arachidonic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MGL | - |
Rattus norvegicus |
monoacylglycerol lipase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | MGL inhibitors suppress formalin-induced pain through peripheral cannabinoid receptor 1 and cannabinoid receptor 2 receptor mechanisms. MGL inhibition increases paw skin 2-arachidonoylglycerol accumulation to mediate these effects | Rattus norvegicus |