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Literature summary for 3.1.1.23 extracted from
- CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay (2008), ChemBioChem, 9, 2704-2710.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arachidonoyltrifluoromethylketone | - |
Homo sapiens |  |
| benzylphenylcarbamate | - |
Homo sapiens | |
| CAY10499 | - |
Homo sapiens | |
| Disulfiram | - |
Homo sapiens | |
| methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14- tetraenylphosphonofluoridate | completely inhibits 4-nitophenyl acetate hydrolysis by pure human MGL at 0.1 mM | Homo sapiens | |
| additional information | not inhibited by CAY10433, WWL70, and URB602 | Homo sapiens | |
| N-arachidonylmaleimide | - |
Homo sapiens | |
| N-benzoylthiocarbamic cyclohexylethyl ester | - |
Homo sapiens | |
| N-ethylmaleimide | - |
Homo sapiens | |
| phenylmethylsulfonyl fluoride | inhibits MGL only at very high concentrations | Homo sapiens | |
| tetrahydrolipstatin | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
4-nitrophenyl acetate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-arachidonoylglycerol + H2O | - |
Homo sapiens | arachidonic acid + glycerol | - |
? | |
| 2-oleoylglycerol + H2O | - |
Homo sapiens | oleic acid + glycerol | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MGL | - |
Homo sapiens |
| monoglycerid lipase | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000076 | - |
- |
Homo sapiens | methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate | |
| 0.0004 | - |
using 2-oleoylglycerol as a substrate | Homo sapiens | CAY10499 | |
| 0.00046 | - |
- |
Homo sapiens | tetrahydrolipstatin | |
| 0.0005 | - |
using 4-nitophenyl acetate as a substrate | Homo sapiens | CAY10499 | |
| 0.0008 | - |
- |
Homo sapiens | Disulfiram | |
| 0.00184 | - |
- |
Homo sapiens | arachidonoyltrifluoromethylketone | |
| 0.0049 | - |
using 2-oleoylglycerol as a substrate | Homo sapiens | N-arachidonylmaleimide | |
| 0.005 | - |
using 4-nitophenyl acetate as a substrate | Homo sapiens | N-benzoylthiocarbamic cyclohexylethyl ester | |
| 0.0105 | - |
using 4-nitophenyl acetate as a substrate | Homo sapiens | N-arachidonylmaleimide | |
| 0.02 | - |
using 2-oleoylglycerol as a substrate | Homo sapiens | N-benzoylthiocarbamic cyclohexylethyl ester | |
| 0.028 | - |
- |
Homo sapiens | N-ethylmaleimide | |
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