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Literature summary for 3.1.1.2 extracted from

  • Mu, X.; Yu, N.; Wang, C.; Zou, X.; Abulimite, Z.; Xia, Z.
    Evaluation of a new substrate for measurement of serum PON arylesterase activity (2012), Talanta, 88, 711-716.
    View publication on PubMed
Search for more literature for 3.1.1.2

Application

Application Comment Organism
analysis use of 9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate as a substrate for serum PON arylesterase activity assay. The apparent Km value of a serum sample for the substrate is 85 nmol/l, close to the Km value of recombinant human isoform PON1. Recombinant human PON1 in presence of CaCl2 shows at least 7.8 times selectivity over acetylcholinesterase and lipases. The method allows reliable, cost-saving, and specific determination in a buffer of physiological pH Homo sapiens
medicine use of 9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate as a substrate for serum PON arylesterase activity assay. The apparent Km value of a serum sample for the substrate is 85 nmol/l, close to the Km value of recombinant human isoform PON1. Recombinant human PON1 in presence of CaCl2 shows at least 7.8 times selectivity over acetylcholinesterase and lipases. The method allows reliable, cost-saving, and specific determination in a buffer of physiological pH Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
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 9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate Km value of a serum sample is 85 nM, pH 8.0, 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate + H2O
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 Homo sapiens 9-carboxy-10-methylacridinium triflate + 4-chlorophenol
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