Literature summary for 3.1.1.2 extracted from

Renault, F.; Carus, T.; Clery-Barraud, C.; Elias, M.; Chabriere, E.; Masson, P.; Rochu, D.
Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1) (2010), J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 878, 1346-1355.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	binding of human phosphate binding protein amends the size of the oligomeric states and exerts a stabilizing effect on the activity	Homo sapiens
phosphate	-	synthetic construct
phosphate	preserves activity with considerable fluctuations, modulates oligomeric state	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
bacterially expressed chimeric G2E6	synthetic construct

Crystallization (Commentary)

Crystallization (Comment)	Organism
phosphate ion is bound to the catalytic calcium in the structure of crystallized recombinant G2E6	synthetic construct

Inhibitors

Inhibitors	Comment	Organism	Structure
2-hydroxyquinoline	70% inhibition	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	is essential for activity and stability of arylesterase, modulates oligomeric state	Homo sapiens
Ca2+	is essential for activity and stability of arylesterase, modulates oligomeric state	synthetic construct

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
synthetic construct	-	chimeric mammalian dubbed G3C9-8His, obtained using directed evolution via gene shuffling of human, rabbit, rat and mouse genes	-

Purification (Commentary)

Purification (Comment)	Organism
by pseudo-affinity chromatography and gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
plasma	-	Homo sapiens	-

Storage Stability

Storage Stability	Organism
4°C, 50 mM Tris buffer, 50 mM NaCl, 1 mM CaCl2, 0.1% tergitol, pH 8.0, 1 month	Homo sapiens
4°C, 50 mM Tris buffer, 50 mM NaCl, 1 mM CaCl2, 0.1% tergitol, pH 8.0, 1 month	synthetic construct

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phenyl acetate + H2O	-	Homo sapiens	phenol + acetate	-	?
phenyl acetate + H2O	-	synthetic construct	phenol + acetate	-	?

Synonyms

Synonyms	Comment	Organism
arylesterase	-	Homo sapiens
arylesterase	-	synthetic construct

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Release 2023.1 (January 2023)