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Literature summary for 3.1.1.2 extracted from

  • Abraham, P.; Sugumar, E.
    Increased glutathione levels and activity of PON1 (phenyl acetate esterase) in the liver of rats after a single dose of cyclophosphamide: a defense mechanism? (2008), Exp. Toxicol. Pathol., 59, 301-306.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cyclophosphamide 22% increase in the activity of PON1 in the liver and 23% increase in PON1 activity in the serum is observed 24 h after treatment with a single dose of 150 mg/kg cyclophosphamide Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P55159
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
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serum
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phenyl acetate + H2O
-
Rattus norvegicus phenol + acetate
-
?

Synonyms

Synonyms Comment Organism
phenyl acetate esterase
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Rattus norvegicus