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Literature summary for 3.1.1.2 extracted from
- Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position (2006), Biochim. Biophys. Acta, 1758, 499-508.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1-palmitoyl-2-arachidonoylphosphatidylcholine | stimulates arylesterase activity | Homo sapiens |  |
| 1-palmitoyl-2-linoleoylphosphatidylcholine | stimulates arylesterase activity | Homo sapiens | |
| didecanoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| dilauroylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| dilinoleoylphosphatidylcholine | stimulates arylesterase activity | Homo sapiens | |
| dimyristoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| dimyristoylphosphatidylglycerol | activates the arylesterase activity and inhibits paraoxonase activity | Homo sapiens | |
| dipalmitoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| phosphatidylinositol | enhances arylesterase activity, but slightly decreases paraoxonase activity | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dimyristoylphosphatidic acid | 0.4 mM, 81% inhibition of arylesterase activity, 64% inhibition of paraoxonase activity | Homo sapiens | |
| dimyristoylphosphatidylserine | no significant inhibition of both paraoxonase and arylesterase activity up to 0.030 mM, remarkable inhibition of both activities at 0.10.4 mM, with a greater inhibition of arylesterase activity | Homo sapiens | |
| additional information | 0.2 mM dimyristoylphosphatidylethanol inhibits paraoxonase activity but has no effect on arylesterase activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27169 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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