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Literature summary for 3.1.1.17 extracted from
- Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1) (2009), Biochim. Biophys. Acta, 1790, 155-160.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate/Cu2+ | oxidative system ascorbate/Cu2+ is the most potent in inactivating the lactonase activity of purified PON1, 0.5 mM/0.001 mM: up to 100% inhibition, 0.1 mM/0.001 mM: 90% inhibition, 95%-100% inhibition. Oleic acid prevents the ascorbate/Cu2+-induced inactivation | Homo sapiens |  |
| ascorbate/Fe2+ | 0.5 mM/0.002 mM: 20% inhibiiton | Homo sapiens | |
| Cu2+ | 0.001 mM, 30% inhibition | Homo sapiens | |
| NaOCl | 1 mM, 20% inhibition | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using different types of chromatographies | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| valerolactone + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| human paraoxonase 1 | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.3 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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