Cloned (Comment) | Organism |
---|---|
expressed in HEK-293A cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-AS115 | non-selective inhibitor | Mus musculus | |
(-)-AS115 | non-selective inhibitor | Mus musculus | |
76-0079 | - |
Mus musculus | |
additional information | not inhibited by orlistat and benzil | Mus musculus | |
paraoxon | selective inhibitor | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BLF1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
peritoneal macrophage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl oleate + H2O | - |
Mus musculus | cholesterol + oleic acid | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
NCEH | - |
Mus musculus |
Nceh1 | - |
Mus musculus |
neutral CE hydrolase 1 | - |
Mus musculus |
neutral cholesteryl ester hydrolase 1 | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
pH and temperature not specified in the publication | Mus musculus | paraoxon | |
0.0001 | - |
pH and temperature not specified in the publication | Mus musculus | (-)-AS115 | |
0.0003 | - |
pH and temperature not specified in the publication | Mus musculus | (+)-AS115 | |
0.0023 | - |
pH and temperature not specified in the publication | Mus musculus | 76-0079 |
Organism | Comment | Expression |
---|---|---|
Mus musculus | enzyme activity is not increased by overexpression of Ces3 | additional information |
Mus musculus | enzyme activity is increased 24.9fold by overexpression of hormone-sensitive lipase | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays a dominant role over hormone-sensitive lipase in the hydrolysis of cholesteryl ester and subsequent cholesterol efflux in mouse peritoneal macrophages | Mus musculus |