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Literature summary for 3.1.1.13 extracted from

  • Ohta, K.; Sekiya, M.; Uozaki, H.; Igarashi, M.; Takase, S.; Kumagai, M.; Takanashi, M.; Takeuchi, Y.; Izumida, Y.; Kubota, M.; Nishi, M.; Okazaki, H.; Iizuka, Y.; Yahagi, N.; Yagyu, H.; Fukayama, M.; Kadowaki, T.; Ohashi, K.; Ishibashi, S.; Osuga, J.
    Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement (2011), Biochem. Biophys. Res. Commun., 404, 254-260.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
microsome
-
Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Mus musculus
-
brain
-
Mus musculus
-
heart
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
white adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesteryl oleate + H2O
-
Mus musculus cholesterol + oleate
-
?

Synonyms

Synonyms Comment Organism
Nceh1
-
Mus musculus
neutral cholesterol ester hydrolase 1
-
Mus musculus

General Information

General Information Comment Organism
malfunction hormone-sensitive lipase deficiency remarkably reduces the neutral cholesterol ester hydrolase activity in adrenal glands. Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement Mus musculus
physiological function Nceh1 is involved in the adrenal cholesterol metabolism, and the cholesterol ester hydrolytic activity in adrenal glands is associated with the organ enlargement Mus musculus