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Literature summary for 3.1.1.13 extracted from

  • Pietsch, M.; Gutschow, M.
    Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition (2005), J. Med. Chem., 48, 8270-8288.
    View publication on PubMed
Search for more literature for 3.1.1.13

Inhibitors

Inhibitors Comment Organism Structure
2-(diethylamino)-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-(diethylamino)-5,6-dimethyl-4H-thieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-(diethylamino)-5-isopropyl-4H-thieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-(diethylamino)-5-methyl-5,6,7,8-tetrahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-(diethylamino)-6,7,8,9-tetrahydro-4H,5H-cyclohepta(4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-(dimethylamino)-1,2,5,6,7,8-hexahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-(dimethylamino)-1,5,6,7-tetrahydro-2H,4H-cyclopenta(4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-(dimethylamino)-1,5,6,8-tetrahydro-2H,4H-thiopyrano(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus
2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-1-benzothieno(2,3-d)(1,3)oxazin-4-one
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0065
-
 (25R)-3beta-hydroxycholest-5-en-27-oate pH 7.0 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(25R)-3beta-hydroxycholest-5-en-27-oate + H2O
-
 Bos taurus ?
-
 ?
2-(dimethylamino)-1,5,6,7-tetrahydro-2H,4H-cyclopenta(4,5)thieno(2,3-d)(1,3)oxazin-4-one + H2O
-
 Bos taurus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00063
-
 2-(dimethylamino)-1,5,6,7-tetrahydro-2H,4H-cyclopenta(4,5)thieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.00164
-
 2-(diethylamino)-5-methyl-5,6,7,8-tetrahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.00215
-
 2-(dimethylamino)-1,2,5,6,7,8-hexahydro-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.0043
-
 2-(diethylamino)-5,6-dimethyl-4H-thieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.0057
-
 2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-1-benzothieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.00576
-
 2-(dimethylamino)-1,5,6,8-tetrahydro-2H,4H-thiopyrano(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.006
-
 2-(diethylamino)-6,7,8,9-tetrahydro-4H,5H-cyclohepta(4,5)thieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.0064
-
 2-(diethylamino)-5-isopropyl-4H-thieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus
0.0075
-
 2-(diethylamino)-4H-(1)benzothieno(2,3-d)(1,3)oxazin-4-one pH 7.0 Bos taurus