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Literature summary for 3.1.1.13 extracted from

  • Sbarra, V.; Ristorcelli, E.; Petit-Thevenin, J.L.; Teissedre, P.L.; Lombardo, D.; Verine, A.
    In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase (2005), Biochim. Biophys. Acta, 1736, 67-76.
    View publication on PubMed

Application

Application Comment Organism
nutrition resveratrol and red wine polyphenolic extracts decrease enzyme activity. In vivo, these effects can decrease hydrolysis of dietary lipid esters and the absorption of free cholesterol Rattus norvegicus
nutrition resveratrol and red wine polyphenolic extraxts decrease enzyme activity. In vivo, these effects can decrease hydrolysis of dietary lipid esters and the absorption of free cholesterol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
resveratrol
-
Homo sapiens
resveratrol
-
Rattus norvegicus
wine polyphenolic extract
-
Homo sapiens
wine polyphenolic extract
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0122
-
p-nitrophenyl hexanoate presence of 0.05 mM/l resveratrol, pH 7.4, 30°C Homo sapiens
0.0142
-
p-nitrophenyl hexanoate pH 7.4, 30°C Homo sapiens
0.0384
-
p-nitrophenyl hexanoate presence of 0.1 mM/l red wine polyphenolic extracts, pH 7.4, 30°C Homo sapiens
0.046
-
p-nitrophenyl caproate presence of 0.05 mM/l resveratrol, pH 7.4, 30°C Rattus norvegicus
0.074
-
p-nitrophenyl caproate pH 7.4, 30°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl caproate + H2O
-
Rattus norvegicus p-nitrophenol + capric acid
-
?
p-nitrophenyl hexanoate + H2O
-
Homo sapiens p-nitrophenol + hexanoic acid
-
?