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Literature summary for 3.1.1.13 extracted from
- Cholesterol esterase activities in commercial pancreatic enzyme preparations and implications for use in pancreatic insufficient cystic fibrosis (2001), J. Clin. Pharm. Ther., 26, 425-431.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3-hydroxy bile salt | dependent on, both hydrolysis and synthesis | Sus scrofa | |
| sodium taurocholate | dependent on, both hydrolysis and synthesis | Sus scrofa |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | pancreatic enzyme preparation is used in human pancreatic cystic fibrosis therapy | Sus scrofa |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Sus scrofa | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Sus scrofa |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| steryl ester + H2O = sterol + fatty acid | a group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | various commercial preparations from pancreas and pure enzyme | Sus scrofa | - |
| pancreas | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol ester + H2O | hydrolysis level greatly exceeds the synthesis level, enzyme can simultaneously perform synthesis and hydrolysis reactions | Sus scrofa | cholesterol + fatty acid | - |
r | |
| oleic acid + cholesterol | - |
Sus scrofa | cholesteryl oleate | - |
r | |
| oleic acid + retinol | - |
Sus scrofa | retinyl oleate | - |
r | |
| retinyl palmitate + H2O | - |
Sus scrofa | retinol + palmitate | - |
r | |
| tocopherol acetate + H2O | - |
Sus scrofa | tocopherol + acetate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bile salt-stimulated lipase | - |
Sus scrofa |
| cholesterol esterase | - |
Sus scrofa |
| pancreatic carboxyl ester hydrolase | - |
Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
hydrolysis in presence of taurocholate | Sus scrofa |
| 5.8 | - |
synthesis in presence of taurocholate | Sus scrofa |
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