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Literature summary for 3.1.1.13 extracted from
- Adrenal neutral cholesteryl ester hydrolase: identification, subcellular distribution, and sex differences (2002), Endocrinology, 143, 801-806.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | inactivation of the hormone-sensitive lipase HSL by homologous recombination leads to 98% reduction of cholesteryl esterase activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inactivation of the hormone-sensitive lipase HSL by homologous recombination leads to 98% reduction of cholesteryl esterase activity | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | low activity | Rattus norvegicus | 5829 | - |
| microsome | main activity | Rattus norvegicus | - |
- |
| mitochondrion | low activity | Rattus norvegicus | 5739 | - |
| nucleus | low activity | Rattus norvegicus | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
activity in male rats is higher than in female rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00025 | - |
female rat mutant lacking HSL activity | Rattus norvegicus |
| 0.00032 | - |
male rat mutant lacking HSL activity | Rattus norvegicus |
| 0.016 | - |
femal rat adrenal | Rattus norvegicus |
| 0.028 | - |
male rat adrenal | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl oleate + H2O | - |
Rattus norvegicus | cholesterol + oleate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CEH | - |
Rattus norvegicus |
| neutral cholesteryl ester hydrolase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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