Literature summary for 3.1.1.13 extracted from

Heidrich, J.E.; Contos, L.M.; Hunsaker, L.A.; Deck, L.M.; Vander Jagt, D.L.
Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster (2004), BMC Pharmacol., 4, 5.

Search for more literature for 3.1.1.13

Application

Application	Comment	Organism
medicine	selective inhibitors may be useful therapeutics for limiting cholesterol absorption	Mesocricetus auratus

Inhibitors

Inhibitors	Comment	Organism	Structure
3-benzyl-6-chloro-2-pyrone	less selective, potent inhibitor	Mesocricetus auratus
6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone	selective, potent, and reversible inhibitor, not toxic in vivo, enzyme inhibition effectively reduces cholesterol uptake in vivo	Mesocricetus auratus
additional information	substituted 6-chloro-2-pyrones can be simple reversible inhibitors or irreversible active site inhibitors where an active site nucleophile attacks the 6-postion of the pyrone with release of chloride	Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cholesteryl oleate + H2O	Mesocricetus auratus	-	cholesterol + oleate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mesocricetus auratus	-	male	-

Reaction

Reaction	Comment	Organism	Reaction ID
steryl ester + H2O = sterol + fatty acid	a group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts	Mesocricetus auratus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Mesocricetus auratus	-
pancreas	-	Mesocricetus auratus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cholesteryl oleate + H2O	-	Mesocricetus auratus	cholesterol + oleate	-	?

Synonyms

Synonyms	Comment	Organism
CEase	-	Mesocricetus auratus
cholesterol esterase	-	Mesocricetus auratus

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Release 2023.1 (January 2023)