Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | esterification doubled | Homo sapiens | |
2-mercaptoethanol | esterification doubled | Rattus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ammonium chloride | slightly inhibitory | Homo sapiens | |
ammonium chloride | slightly inhibitory | Rattus sp. | |
Chloroquine | 90% inhibition at 30 mM | Homo sapiens | |
Chloroquine | 90% inhibition at 30 mM | Rattus sp. | |
progesterone | marked inhibition, additive effect if chloroquine is present | Homo sapiens | |
progesterone | marked inhibition, additive effect if chloroquine is present | Rattus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Rattus sp. | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl esters + H2O | Homo sapiens | involvement in arteriosclerosis | cholesterol + fatty acid | - |
r | |
cholesteryl esters + H2O | Rattus sp. | involvement in arteriosclerosis | cholesterol + fatty acid | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus sp. | - |
Storage Stability | Organism |
---|---|
-20°C, 80% loss of activity, 2 weeks | Homo sapiens |
-20°C, 80% loss of activity, 2 weeks | Rattus sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl esters + H2O | involvement in arteriosclerosis | Homo sapiens | cholesterol + fatty acid | - |
r | |
cholesteryl esters + H2O | involvement in arteriosclerosis | Rattus sp. | cholesterol + fatty acid | - |
r | |
cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleic acid | - |
r | |
cholesteryl oleate + H2O | - |
Rattus sp. | cholesterol + oleic acid | - |
r |
Synonyms | Comment | Organism |
---|---|---|
acid cholesterol esterase | - |
Homo sapiens |
acid cholesterol esterase | - |
Rattus sp. |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
90 | - |
complete loss of activity after 15 min | Homo sapiens |
90 | - |
complete loss of activity after 15 min | Rattus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | - |
for synthesis of cholesteryl esters | Homo sapiens |
4 | - |
for synthesis of cholesteryl esters | Rattus sp. |
4.5 | - |
hydrolysis of cholesteryl esters | Homo sapiens |
4.5 | - |
hydrolysis of cholesteryl esters | Rattus sp. |
6 | - |
- |
Homo sapiens |
6 | - |
- |
Rattus sp. |
8 | - |
- |
Homo sapiens |
8 | - |
- |
Rattus sp. |