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Literature summary for 3.1.1.13 extracted from
- Inhibition of cholesterylester accumulation by 17beta-estradiol in macrophages through activation of neutral cholesterol esterase (1996), Biochim. Biophys. Acta, 1300, 210-218.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 17beta-estradiol | enhanced hydrolysis of cholesteryl oleate in time- and dose-dependent manner | Mus musculus |  |
| cAMP-dependent protein kinase type II | increasing activity on cholesteryl oleate hydrolysis, increasing protein kinase synthesis due to addition of 17beta-estradiol | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| progesterone | 38% inhibition at 0.06 mM | Mus musculus | |
| testosterone | 19% inhibition at 0.035 mM | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.005 | - |
cholesteryl oleate | in presence of cofactors | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activation in a reaction mixture containing cAMP, protein kinase A and ATP | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | Mus musculus | involvement in arteriosclerosis | cholesterol + fatty acid | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | J774 A.1 cells | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | involvement in arteriosclerosis | Mus musculus | cholesterol + fatty acid | - |
r | |
| cholesteryl oleate + H2O | - |
Mus musculus | cholesterol + oleic acid | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| N-CEase | - |
Mus musculus |
| neutral cholesterol esterase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | as cofactor for cAMP-dependent protein kinase | Mus musculus | |
| MgATP2- | - |
Mus musculus | |
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