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Literature summary for 3.1.1.13 extracted from
- Purification and identification of two distinct isoforms of rabbit pancreatic cholesterol esterase (1995), Int. J. Biochem. Cell Biol., 27, 415-423.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| sodium taurocholic acid | - |
Oryctolagus cuniculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| heparin | 50% inhibition for CEase-ISF II at 0.025 mM, no inhibition for CEase-IF I | Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
SDS-PAGE for CEase-ISF I and CEase-ISF II | Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | Oryctolagus cuniculus | - |
cholesterol + fatty acid | - |
? | |
| fat-soluble vitamin esters + H2O | Oryctolagus cuniculus | - |
vitamin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
rabbit | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, 70fold for CEase-ISF I and 45fold for CEase-IF II, chromatography techniques | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | - |
Oryctolagus cuniculus | cholesterol + fatty acid | - |
? | |
| cholesteryl oleate + H2O | - |
Oryctolagus cuniculus | cholesterol + oleic acid | - |
? | |
| fat-soluble vitamin esters + H2O | - |
Oryctolagus cuniculus | vitamin + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 66000, SDS-PAGE | Oryctolagus cuniculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CEase | - |
Oryctolagus cuniculus |
| CEase ISF I | - |
Oryctolagus cuniculus |
| CEase ISF II | - |
Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
for both isoforms CEase-ISF I and -ISF II, higher pH reduces hydrolytic activity for 60% | Oryctolagus cuniculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
heparin | for CEase-ISF II | Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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