Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | not affected by dithiothreitol | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D77N/D78N | hydrolysis of O-acetyl-D-ADP-ribose is abolished by these mutations | Homo sapiens |
E238Q/E239Q | the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose | Homo sapiens |
E261Q/E262Q | the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP-D-ribose | competitive inhibitor | Homo sapiens | |
additional information | D-ribose 5-phosphate, AMP, ADP and beta-NAD have relatively little inhibitory effect on the enzyme activity | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on Mg2+. 1 mM is used in assay conditions | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
O-acetyl-ADP-D-ribose + H2O | Homo sapiens | - |
ADP-D-ribose + acetate | - |
? | |
poly(ADP-D-ribose) + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
O-acetyl-ADP-D-ribose + H2O | - |
Homo sapiens | ADP-D-ribose + acetate | - |
? | |
poly(ADP-D-ribose) + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 39000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ARH3 | - |
Homo sapiens |
O-acetyl-ADP-ribose hydrolase | - |
Homo sapiens |
poly(ADP-ribose) glycohydrolase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
ADP-D-ribose | at pH 7.0 and 30°C | Homo sapiens |