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Literature summary for 3.1.1.106 extracted from
- The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases (2006), Proc. Natl. Acad. Sci. USA, 103, 16687-16691 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not affected by dithiothreitol | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D77N/D78N | hydrolysis of O-acetyl-D-ADP-ribose is abolished by these mutations | Homo sapiens |
| E238Q/E239Q | the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose | Homo sapiens |
| E261Q/E262Q | the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP-D-ribose | competitive inhibitor | Homo sapiens |  |
| additional information | D-ribose 5-phosphate, AMP, ADP and beta-NAD have relatively little inhibitory effect on the enzyme activity | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | dependent on Mg2+. 1 mM is used in assay conditions | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-acetyl-ADP-D-ribose + H2O | Homo sapiens | - |
ADP-D-ribose + acetate | - |
? | |
| poly(ADP-D-ribose) + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-acetyl-ADP-D-ribose + H2O | - |
Homo sapiens | ADP-D-ribose + acetate | - |
? | |
| poly(ADP-D-ribose) + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 39000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ARH3 | - |
Homo sapiens |
| O-acetyl-ADP-ribose hydrolase | - |
Homo sapiens |
| poly(ADP-ribose) glycohydrolase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
ADP-D-ribose | at pH 7.0 and 30°C | Homo sapiens | |
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