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Literature summary for 3.1.1.103 extracted from

  • Zhao, Y.; Verma, V.; Belcheva, A.; Singh, A.; Fridman, M.; Golemi-Kotra, D.
    Staphylococcus aureus methicillin-resistance factor fmtA is regulated by the global regulator SarA (2012), PLoS ONE, 7, e43996 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.103

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O Staphylococcus aureus
-
 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O Staphylococcus aureus RN4220
-
 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus RN4220
-
-
-

Purification (Commentary)

Purification (Comment) Organism
SP-Sepharose column chromatography and Superdex 75 gel filtration Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O
-
 Staphylococcus aureus [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O
-
 Staphylococcus aureus RN4220 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Synonyms

Synonyms Comment Organism
fmtA
-
 Staphylococcus aureus

Expression

Organism Comment Expression
Staphylococcus aureus SarA is essential for the induction of enzyme expression by cell wall-specific antibiotic up

General Information

General Information Comment Organism
physiological function the enzyme is part of the core cell wall stimulon and is involved in methicillin resistance in Staphylococcus aureus Staphylococcus aureus