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Literature summary for 3.1.1.103 extracted from

  • Komatsuzawa, H.; Ohta, K.; Labischinski, H.; Sugai, M.; Suginaka, H.
    Characterization of fmtA, a gene that modulates the expression of methicillin resistance in Staphylococcus aureus (1999), Antimicrob. Agents Chemother., 43, 2121-2125 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.103

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli HMS174 cells Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Staphylococcus aureus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O Staphylococcus aureus
-
 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O Staphylococcus aureus KSA8
-
 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus O50608
-
-
Staphylococcus aureus KSA8 O50608
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O
-
 Staphylococcus aureus [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O
-
 Staphylococcus aureus KSA8 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Synonyms

Synonyms Comment Organism
fmtA
-
 Staphylococcus aureus

Expression

Organism Comment Expression
Staphylococcus aureus the transcription of the enzyme is not changed by the addition of vancomycin or tetracycline additional information
Staphylococcus aureus the transcription of the enzyme is dose dependently increased by the addition of beta-lactam antibiotics, fosfomycin, and bacitracin up

General Information

General Information Comment Organism
physiological function the enzyme affects the methicillin resistance level in methicillin-resistant Staphylococcus aureus Staphylococcus aureus