Application | Comment | Organism |
---|---|---|
drug development | development and application of hiCE-specific inhibitors designed to selectively modulate drug hydrolysis in vivo | Homo sapiens |
pharmacology | development and application of hiCE-specific inhibitors designed to selectively modulate drug hydrolysis in vivo | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | - |
Homo sapiens | |
(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate | - |
Homo sapiens | |
2,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
2,5-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
3,4-difluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
3,4-difluoro-N-(4-(phenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
4,6-dimethyl-N1,N3-diphenylbenzene-1,3-disulfonamide | - |
Homo sapiens | |
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-3-methylbenzoic acid | - |
Homo sapiens | |
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)-N-methyl benzamide | - |
Homo sapiens | |
4-(N-(4-(4-fluorophenylsulfonamido)phenyl)sulfamoyl)benzoic acid | - |
Homo sapiens | |
4-bromo-N-(4-ethoxyphenyl)benzene sulfonamide | - |
Homo sapiens | |
4-chloro-N-(4-(4-fluorophenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
4-chloro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
4-chloro-N-(4-ethoxyphenyl)benzene sulfonamide | - |
Homo sapiens | |
4-fluoro-N-(4-(4-methoxy phenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
4-fluoro-N-(4-(4-methylphenylsulfonamido)phenyl)benzene sulfonamide | - |
Homo sapiens | |
7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin | i.e. irinotecan or CPT-11, an antitumor prodrug | Homo sapiens | |
additional information | development and evaluation of a class of benzene sulfonamide inhibitors, quantitative structure-activity relationship, QSAR, modeling, overview | Homo sapiens | |
N,N'-(1,4-phenylene)bis(2,3-dichlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(2,4,5-trichlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(2,5-dichlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(2,6-difluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(2-fluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3,4,5-trifluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3,4-difluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3,5-difluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3-bromobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3-chlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(3-fluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(4-bromobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(4-chlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(4-fluoro-2-methylbenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(1,4-phenylene)bis(4-fluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-fluoro-1,4-phenylene)bis(4-chlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetrafluoro-1,4-phenylene)bis(4-bromobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,4-dichlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3,5-dichlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-bromobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(3-chlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-bromobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-chlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(4-fluorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,5-dibromo-1,4-phenylene)bis(4-chlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2,5-dibromo-1,4-phenylene)bisbenzene sulfonamide | - |
Homo sapiens | |
N,N'-(2,5-dichloro-1,4-phenylene)bis(4-chlorobenzene sulfonamide) | - |
Homo sapiens | |
N,N'-(2-chloro-1,4-phenylene)dibenzene sulfonamide | - |
Homo sapiens | |
N,N'-(2-methyl-1,4-phenylene)benzene sulfonamide | - |
Homo sapiens | |
N,N'-(2-methylbenzene-1,4-diyl)dibenzenesulfonamide | - |
Homo sapiens | |
N,N'-(disulfanediyldibenzene-4,1-diyl)dimethanesulfonamide | - |
Homo sapiens | |
N,N'-1,4-phenylenebis-2-naphthalene sulfonamide | - |
Homo sapiens | |
N,N'-9H-fluorene-2,7-diylbis(3,4,5-trifluorobenzenesulfonamide) | - |
Homo sapiens | |
N,N'-9H-fluorene-2,7-diylbis(3-bromobenzenesulfonamide) | - |
Homo sapiens | |
N,N'-9H-fluorene-2,7-diylbis(3-chlorobenzenesulfonamide) | - |
Homo sapiens | |
N,N'-9H-fluorene-2,7-diylbis(4-chlorobenzenesulfonamide) | - |
Homo sapiens | |
N,N'-9H-fluorene-2,7-diyldibenzenesulfonamide | - |
Homo sapiens | |
N,N'-benzene-1,4-diyldibenzenesulfonamide | - |
Homo sapiens | |
N-(4-(4-fluoromethylphenylsulfonamido)phenyl)-2,5-dimethylbenzene sulfonamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes CE1 and intestinal CE | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | human intestinal CE, hiCE | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HCE1 | - |
Homo sapiens |
hiCE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000079 | - |
- |
Homo sapiens | N,N'-9H-fluorene-2,7-diylbis(3,4,5-trifluorobenzenesulfonamide) | |
0.0000252 | - |
- |
Homo sapiens | N,N'-9H-fluorene-2,7-diylbis(4-chlorobenzenesulfonamide) | |
0.0000984 | - |
- |
Homo sapiens | N,N'-9H-fluorene-2,7-diyldibenzenesulfonamide | |
0.0001 | - |
- |
Homo sapiens | N,N'-9H-fluorene-2,7-diylbis(3-chlorobenzenesulfonamide) | |
0.00057 | - |
- |
Homo sapiens | N,N'-9H-fluorene-2,7-diylbis(3-bromobenzenesulfonamide) |