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Literature summary for 2.9.1.1 extracted from
- Selenocysteine synthase from Escherichia coli. Analysis of the reaction sequence (1991), J. Biol. Chem., 266, 6324-6328.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Seryl-tRNASec + selenophosphate | Escherichia coli | the enzyme is involved in the biosynthesis of selenocysteine | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate | the formyl group of pyridoxal phosphate forms a Schiff base with the alpha-amino group of L-Ser with the subsequent 2,3-elimination of a water molecule and the generation of an aminoacrylyl-tRNASecUCA intermediate | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Seryl-tRNASec + selenophosphate | - |
Escherichia coli | L-Selenocysteinyl-tRNASec + H2O + phosphate | - |
? | |
| L-Seryl-tRNASec + selenophosphate | the enzyme is involved in the biosynthesis of selenocysteine | Escherichia coli | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | enzyme contains pyridoxal-phosphate | Escherichia coli | |
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