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Literature summary for 2.8.4.1 extracted from

  • Dey, M.; Kunz, R.C.; Van Heuvelen, K.M.; Craft, J.L.; Horng, Y.C.; Tang, Q.; Bocian, D.F.; George, S.J.; Brunold, T.C.; Ragsdale, S.W.
    Spectroscopic and computational studies of reduction of the metal versus the tetrapyrrole ring of coenzyme F430 from methyl-coenzyme M reductase (2006), Biochemistry, 45, 11915-11933.
    View publication on PubMedView publication on EuropePMC
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Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ in the coenzyme F430, a redox-active nickel tetrahydrocorphin bound at the active site Methanothermobacter marburgensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Methanothermobacter marburgensis the enzyme catalyzes the final step in methane biosynthesis by methanogenic archaea ?
-
 ?

Organism

Organism UniProt Comment Textmining
Methanothermobacter marburgensis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme Methanothermobacter marburgensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the final step in methane biosynthesis by methanogenic archaea Methanothermobacter marburgensis ?
-
 ?

Synonyms

Synonyms Comment Organism
MCR
-
 Methanothermobacter marburgensis
methyl-coenzyme M reductase
-
 Methanothermobacter marburgensis

Cofactor

Cofactor Comment Organism Structure
coenzyme F430 a redox-active nickel tetrahydrocorphin bound at the active site, contains low-spin Ni(II), determination of the cofactor reduction site at the exocyclic ketone group by NMR study, mass spectrometry, and QM/MM computations, conversion of F430 to F330 reduces the hydrocorphin ring but not the metal, reduction of F430 with Ti(III) citrate to generate F380, corresponding to the active MCRred1 state, reduces the Ni(II) to Ni(I) but does not reduce the tetrapyrrole ring system, overview Methanothermobacter marburgensis