BRENDA - Enzyme Database show
show all sequences of 2.8.3.8

ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma

Millerioux, Y.; Morand, P.; Biran, M.; Mazet, M.; Moreau, P.; Wargnies, M.; Ebikeme, C.; Deramchia, K.; Gales, L.; Portais, J.C.; Boshart, M.; Franconi, J.M.; Bringaud, F.; J. Biol. Chem. 287, 17186-17197 (2012)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Trypanosoma brucei
5739
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Trypanosoma brucei
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinate + acetyl-CoA
-
725472
Trypanosoma brucei
acetate + succinyl-CoA
-
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Trypanosoma brucei
5739
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinate + acetyl-CoA
-
725472
Trypanosoma brucei
acetate + succinyl-CoA
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
the acetate:succinate CoA-transferase null mutant is about 1000times more sensitive to oligomycin, a specific inhibitor of the mitochondrial F0/F1-ATP synthase, than wild type cells
Trypanosoma brucei
metabolism
the enzyme is involved in ATP production in the mitochondrion
Trypanosoma brucei
General Information (protein specific)
General Information
Commentary
Organism
malfunction
the acetate:succinate CoA-transferase null mutant is about 1000times more sensitive to oligomycin, a specific inhibitor of the mitochondrial F0/F1-ATP synthase, than wild type cells
Trypanosoma brucei
metabolism
the enzyme is involved in ATP production in the mitochondrion
Trypanosoma brucei
Other publictions for EC 2.8.3.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737509
Trachsel
Function and phylogeny of bact ...
Butyricicoccus porcorum, Eubacterium nodatum, Eubacterium nodatum 68-3-10, Megasphaera elsdenii 14-14, Megasphaera elsdenii
Appl. Environ. Microbiol.
82
6788-6798
2016
-
-
3
-
-
-
-
-
-
-
-
5
-
5
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
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5
-
-
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-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737906
Shaw
Anaerobic detoxification of ac ...
Thermoanaerobacterium saccharolyticum, Thermoanaerobacterium saccharolyticum M2212
Biotechnol. Biofuels
8
75
2015
-
-
-
-
-
-
-
-
-
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2
-
4
-
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-
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2
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2
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2
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738737
Deng
Driving carbon flux through ex ...
Thermoanaerobacterium thermosaccharolyticum, Thermoanaerobacterium thermosaccharolyticum DSM 571
J. Biotechnol.
216
151-157
2015
-
-
1
-
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2
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7
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2
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1
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2
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2
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-
721675
Mullins
Crystal structures of Acetobac ...
Acetobacter aceti
Biochemistry
51
8422-8434
2012
-
-
1
1
6
-
1
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
6
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
1
6
-
-
1
1
1
-
-
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-
-
-
-
1
-
-
-
-
6
-
-
-
-
1
-
-
-
-
-
2
2
-
18
18
725472
Millerioux
ATP synthesis-coupled and -unc ...
Trypanosoma brucei
J. Biol. Chem.
287
17186-17197
2012
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
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1
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2
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
724855
Louis
Diversity of human colonic but ...
Anaerostipes caccae, Anaerostipes caccae DSM 14662, Butyrivibrio fibrisolvens 16/4, Butyrivibrio fibrisolvens, Eubacterium hallii, Eubacterium hallii M72/1, Eubacterium rectale, Eubacterium rectale DSM 17629, Faecalibacterium prausnitzii, Faecalibacterium prausnitzii A2-165, Faecalibacterium prausnitzii L2-6, Faecalibacterium prausnitzii M21/2, Roseburia intestinalis, Roseburia intestinalis L1-82, Roseburia inulinivorans, Roseburia inulinivorans A2-194
Environ. Microbiol.
12
304-314
2010
-
-
-
-
-
-
-
-
-
-
-
-
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24
-
-
-
-
-
2
-
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2
-
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-
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-
-
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-
-
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-
-
-
690517
Louis
Development of a semiquantitat ...
Anaerostipes caccae, Eubacterium hallii, Faecalibacterium prausnitzii, Roseburia hominis, Roseburia hominis A2-183
Appl. Environ. Microbiol.
73
2009-2012
2007
-
4
-
-
-
-
-
-
-
-
-
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5
-
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4
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-
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-
-
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-
-
-
-
646005
Duncan
Acetate utilization and butyry ...
Coprococcus sp., Coprococcus sp. L2-50, Faecalibacterium prausnitzii, Roseburia intestinalis, Roseburia intestinalis L1-82, Roseburia sp., Roseburia sp. A2-181
Appl. Environ. Microbiol.
68
5186-5190
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
14
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
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-
-
-
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-
14
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646006
Korolev
Autotracing of Escherichia col ...
Escherichia coli
Acta Crystallogr. Sect. D
58
2116-2121
2002
-
-
1
1
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
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1
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1
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1
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1
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1
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-
646004
Vanderwinkel
Growth of Escherichia coli on ...
Escherichia coli
Biochem. Biophys. Res. Commun.
33
902-908
1968
-
-
-
-
-
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1
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1
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1
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4
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1
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1
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4
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