Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | rat heart mitochondria at 4, 13, 19, and 24 months of age | Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
subunits 2 * 58000, SDS-PAGE, immunostaining and Coomassie Blue | Rattus norvegicus |
120000 | - |
SDS-PAGE, immunostaining and Coomassie Blue, dimer | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + a 3-oxo acid | Rattus norvegicus | - |
succinate + a 3-oxoacyl-CoA | - |
? | |
succinyl-CoA + acetoacetate | Rattus norvegicus | involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production | succinate + acetoacetyl-CoA | - |
r | |
succinyl-CoA + beta-hydroxybutyrate | Rattus norvegicus | - |
succinate + beta-hydroxybutyryl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Male Fisher rats of different ages | - |
Purification (Comment) | Organism |
---|---|
gel filtration | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
hindlimb | skeletal muscle | Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
additional information | no activity in testis and liver | Rattus norvegicus | - |
skeletal muscle | of hind limb | Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + a 3-oxo acid | - |
Rattus norvegicus | succinate + a 3-oxoacyl-CoA | - |
? | |
succinyl-CoA + acetoacetate | involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production | Rattus norvegicus | succinate + acetoacetyl-CoA | - |
r | |
succinyl-CoA + acetoacetate | here we report the novel finding that tryptophan 372, located in close vicinity of the enzyme active site, is a specific in vivo target of nitration/oxidation, and that the amount of SCOT nitration and activity increase with age | Rattus norvegicus | succinate + acetoacetyl-CoA | - |
r | |
succinyl-CoA + beta-hydroxybutyrate | - |
Rattus norvegicus | succinate + beta-hydroxybutyryl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCOT | - |
Rattus norvegicus |
SCOT1 | - |
Rattus norvegicus |
succinyl-CoA:3-ketoacid coenzyme A transferase | - |
Rattus norvegicus |