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show all sequences of 2.8.3.13

C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA

Marlaire, S.; Van Schaftingen, E.; Veiga-da-Cunha, M.; J. Inherit. Metab. Dis. 37, 13-19 (2014)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells and HEK-293T cells
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
R336W
inactive
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
x * 50000, SDS-PAGE
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9HAC7
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxy-3-methylglutaryl-CoA + glutarate
highest activity
738808
Homo sapiens
3-hydroxy-3-methylglutarate + glutaryl-CoA
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + succinate
-
738808
Homo sapiens
3-hydroxy-3-methylglutarate + succinyl-CoA
-
-
-
?
additional information
adipate, 3-hydroxy-3-methylglutarate and itaconate are at least 10% as good as succinate in a reaction where glutaryl-CoA is used as CoA donor. Other, shorter (malonate, methylmalonate) or more polar (D- and L-2-hydroxyglutarate, malate, alpha-ketoglutarate) are poorer substrates, which react at rates between 1 and 10% of that observed with succinate
738808
Homo sapiens
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 50000, SDS-PAGE
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells and HEK-293T cells
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
R336W
inactive
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
x * 50000, SDS-PAGE
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxy-3-methylglutaryl-CoA + glutarate
highest activity
738808
Homo sapiens
3-hydroxy-3-methylglutarate + glutaryl-CoA
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + succinate
-
738808
Homo sapiens
3-hydroxy-3-methylglutarate + succinyl-CoA
-
-
-
?
additional information
adipate, 3-hydroxy-3-methylglutarate and itaconate are at least 10% as good as succinate in a reaction where glutaryl-CoA is used as CoA donor. Other, shorter (malonate, methylmalonate) or more polar (D- and L-2-hydroxyglutarate, malate, alpha-ketoglutarate) are poorer substrates, which react at rates between 1 and 10% of that observed with succinate
738808
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 50000, SDS-PAGE
Homo sapiens
Other publictions for EC 2.8.3.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738808
Marlaire
C7orf10 encodes succinate-hydr ...
Homo sapiens
J. Inherit. Metab. Dis.
37
13-19
2014
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1
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1
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1
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1
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4
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3
1
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-
-
-
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-
-
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-
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-
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
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-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
643834
Deana
Substrate specificity of a dic ...
Rattus norvegicus
Biochem. Int.
26
767-773
1992
-
-
-
-
-
-
-
56
1
-
-
1
-
1
-
-
1
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-
1
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-
32
-
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-
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-
-
-
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56
1
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1
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1
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1
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-
32
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
643833
Francesconi
Further purification and chara ...
Rattus norvegicus
Biochim. Biophys. Acta
999
163-170
1989
1
-
-
-
-
-
14
4
1
-
1
1
-
1
-
-
1
-
-
1
1
1
2
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
14
-
4
1
-
1
1
-
-
-
1
-
1
1
1
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
643832
Deana
Submitochondrial localization ...
Rattus norvegicus
Biochim. Biophys. Acta
662
119-124
1981
1
-
-
-
-
2
3
3
1
-
1
1
-
1
-
-
1
-
-
1
1
1
3
-
-
-
-
-
1
-
1
-
3
-
-
1
-
-
-
-
-
2
-
3
3
3
1
-
1
1
-
-
-
1
-
1
1
1
3
-
-
-
-
-
1
-
1
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